Purified anti-human GPR56 Antibody

Pricing & Availability
Clone
4C3 (See other available formats)
Other Names
TM7XN1
Isotype
Mouse IgG1, κ
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Product Citations
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4C3_PURE_GPR56_Antibody_1_052517
Human peripheral blood lymphocytes were stained with CD56 Pacific Blue™ and purified GPR56 (clone 4C3) (top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG1 FITC.
  • 4C3_PURE_GPR56_Antibody_1_052517
    Human peripheral blood lymphocytes were stained with CD56 Pacific Blue™ and purified GPR56 (clone 4C3) (top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG1 FITC.
  • 4C3_PURE_GPR56_Antibody_2_052517
Cat # Size Price Quantity Avail. Save
391902 100 µg $245
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Description

GPR56, also known as TM7XN1, is an orphan G-protein-coupled receptor (GPCR) containing seven transmembrane domains and a mucin-like domain in the N-terminal region. The total length of the human GPR56 gene is approximately 15 kb, and it consists of 13 exons and encodes 693 amino acids.  GPR56 is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. Mutations in human GPR56 gene were found to cause a specific brain malformation called bilateral frontoparietal polymicrogyria. Recently, GPR56 was found specifically expressed on cytotoxic NK and T lymphocytes, including CD8+, CD4+, and γδ T cells, which might affect the migratory properties of these cells. GPR56 was also found significantly downregulated in some cancer cells, suggesting that it may play a role in growth suppression and cancer metastasis.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human GPR56 extracellular domain, complete Freund’s adjuvant, incomplete Freund’s adjuvant
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Blocking, Direct ELISA, IP - Reported in the literature

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: blocking the cell migration (1).

Application References

(PubMed link indicates BioLegend citation)
  1. Ohta S, et al. 2015. Biol. Pharm. Bull. 38:594.
RRID
AB_2687290 (BioLegend Cat. No. 391902)

Antigen Details

Structure
Contains seven transmembrane domains and a mucin-like domain in the N-terminal region.
Distribution

T cells, NK cells, wide range of tissues such as brain, thyroid gland, and heart.

Function
May be involved in immune cell migration, cancer cell growth metastasis, and neuron development.
Cell Type
T cells, NK cells
Antigen References

1. Peng YM, et al. 2011. J. Leuko. Biol. 90:735.
2. Shashidhar S, et al. 2005. Oncogene 24:1673.
3. Piao X, et al. 2004. Science 303:2033.
4. Liu M, et al. 1999. Genomics 55:296.

Gene ID
9289 View all products for this Gene ID
UniProt
View information about GPR56 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 0    Revision Date: 05/30/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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