- 4C3 (See other available formats)
- Other Names
- Mouse IgG1, κ
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- Product Citations
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GPR56, also known as TM7XN1, is an orphan G-protein-coupled receptor (GPCR) containing seven transmembrane domains and a mucin-like domain in the N-terminal region. The total length of the human GPR56 gene is approximately 15 kb, and it consists of 13 exons and encodes 693 amino acids. GPR56 is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. Mutations in human GPR56 gene were found to cause a specific brain malformation called bilateral frontoparietal polymicrogyria. Recently, GPR56 was found specifically expressed on cytotoxic NK and T lymphocytes, including CD8+, CD4+, and γδ T cells, which might affect the migratory properties of these cells. GPR56 was also found significantly downregulated in some cancer cells, suggesting that it may play a role in growth suppression and cancer metastasis.Product Details
- Antibody Type
- Host Species
- Human GPR56 extracellular domain, complete Freund’s adjuvant, incomplete Freund’s adjuvant
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
Blocking, Direct ELISA, IP - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: blocking the cell migration (1).
(PubMed link indicates BioLegend citation)
- Ohta S, et al. 2015. Biol. Pharm. Bull. 38:594.
AB_2687290 (BioLegend Cat. No. 391902)
- Contains seven transmembrane domains and a mucin-like domain in the N-terminal region.
T cells, NK cells, wide range of tissues such as brain, thyroid gland, and heart.
- May be involved in immune cell migration, cancer cell growth metastasis, and neuron development.
- Cell Type
- T cells, NK cells
- Antigen References
1. Peng YM, et al. 2011. J. Leuko. Biol. 90:735.
2. Shashidhar S, et al. 2005. Oncogene 24:1673.
3. Piao X, et al. 2004. Science 303:2033.
4. Liu M, et al. 1999. Genomics 55:296.
- Gene ID
- 9289 View all products for this Gene ID
- View information about GPR56 on UniProt.org
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