- CBR-IC3/1 (See other available formats)
- Other Names
- Mouse IgG1, κ
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- Product Citations
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CD50 is a 120-140 kD type I membrane protein also known as intercellular adhesion molecule 3 (ICAM-3). It is broadly expressed on leukocytes, endothelial cells, and Langerhans cells. CD50 is a member of the Ig superfamily. It provides costimulatory signal for T cells and regulates cell adhesion through interaction with LFA-1 (CD11a/CD18, αL/β2) integrin.Product Details
- Human, Baboon, Cynomolgus
- Antibody Type
- Host Species
- SKW3 cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications include: immunoprecipitation1 and blocking1-3.
(PubMed link indicates BioLegend citation)
- deFougerolles AR and Springer TA, et al. 1992. J. Exp. Med. 175:185. (IP, Block)
- Geijtenbeek T, et al. 2000. Cell 100:575. (Block)
- Giannoni E, et al. 2003. J Biol. Chem. 278:36763. (Block)
AB_1186142 (BioLegend Cat. No. 330002)
- Ig superfamily, type I membrane protein, 130 kD
- Thymocytes, T and B cells, monocytes, granulocytes, endothelial cells
- Adhesion, costimulation
- Ligand Receptor
- CD11a/CD18 (LFA-1), integrin αL/ß2
- Cell Type
- Thymocytes, T cells, B cells, Monocytes, Granulocytes, Endothelial cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Costimulatory Molecules
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Valent P, et al. 2001. Immunol. Rev. 179:74.
- Gene ID
- 3385 View all products for this Gene ID
- View information about CD50 on UniProt.org
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