Purified anti-human CD45 Recombinant Antibody

Pricing & Availability
Clone
QA21A24 (See other available formats)
Regulatory Status
RUO
Other Names
CD45, Leukocyte Common Antigen (LCA), T200
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA21A24_PURE_CD45_Antibody_102422
Human peripheral blood lymphocytes were stained with purified anti-human CD45 recombinant (clone QA21A24) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by FITC goat anti-mouse IgG.
  • QA21A24_PURE_CD45_Antibody_102422
    Human peripheral blood lymphocytes were stained with purified anti-human CD45 recombinant (clone QA21A24) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by FITC goat anti-mouse IgG.
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384402 100 µg $123
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Description

CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2927952 (BioLegend Cat. No. 384402)

Antigen Details

Structure
Type I transmembrane protein, 180 – 240 kD (multiple isoforms)
Distribution

Hematopoietic cells, except circulating erythrocytes or platelets

Function
Tyrosine phosphatases, signaling
Cell Type
B cells, Granulocytes, Leukocytes, Lymphocytes, Monocytes, T cells
Biology Area
Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Thomas M. 1989. Annu Rev Immunol. 7:339-69.
  2. Trowbridge I, et al. 1994. Annu Rev Immunol. 12:85-116.
Gene ID
5788 View all products for this Gene ID
UniProt
View information about CD45 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 10/14/2022

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
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  • Purified anti-human CD45 Recombinant Antibody

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