- QA21A24 (See other available formats)
- Regulatory Status
- Other Names
- CD45, Leukocyte Common Antigen (LCA), T200
- Mouse IgG1, κ
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- Product Citations
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CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2927952 (BioLegend Cat. No. 384402)
- Type I transmembrane protein, 180 – 240 kD (multiple isoforms)
Hematopoietic cells, except circulating erythrocytes or platelets
- Tyrosine phosphatases, signaling
- Cell Type
- B cells, Granulocytes, Leukocytes, Lymphocytes, Monocytes, T cells
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
- Thomas M. 1989. Annu Rev Immunol. 7:339-69.
- Trowbridge I, et al. 1994. Annu Rev Immunol. 12:85-116.
- Gene ID
- 5788 View all products for this Gene ID
- View information about CD45 on UniProt.org
|Purified anti-human CD45 Recombinant Antibody||QA21A24||FC|
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