Purified anti-human CD352 (NTB-A) Antibody

Pricing & Availability
NT-7 (See other available formats)
Regulatory Status
HCDM listed
Other Names
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes stained with purified NT-7, followed by anti-mouse IgG FITC
  • NT-7_Pure_082306
    Human peripheral blood lymphocytes stained with purified NT-7, followed by anti-mouse IgG FITC
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317202 100 µg $124
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NTBA (NK-, T-, and B-cell Antigen) is a 60 kD type I transmembrane glycoprotein. It is a member of Ig superfamily belonging to CD2/CD150 subfamily, also known as SLAMF6 (SLAM family member 6), LY108, TCOM, or SF2000. This antigen is expressed on NK cells, T cells (upregulated upon activation), and B cells. NTBA is its own ligand. The homophilic interaction of NTBA is involved in the induction of NK cytotoxicity, CD28 independent T cell costimulation, triggering Th1 cytokines production, and regulation of B cell tolerance. It may play a role in the regulation of autoimmune diseases.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus
Antibody Type
Host Species
Recombinant extracellular domain of NTB-A
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested
Stim - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: stimulation of NTB-A in a redirected lysis assay and blocking of NTB-A function3. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 317211 & 317212). Co-stimulation of cells with CD3 antibodies and clone NT-7 has been shown to induce activation rather than blocking function of these cells3.

Application References

(PubMed link indicates BioLegend citation)
  1. Messmer B, et al. 2006. J. Immunol. 176:4646. (FC)
  2. Ward J, et al. 2007. Blood 110:1207. (FC) PubMed
  3. Uzana R, et al. 2012. J. Immunol. 188:632. (Block) PubMed
  4. Baglaenko Y, et al. 2017. J. Immunol. 198: 3949. (Stim)
Product Citations
  1. Uzana R, et al. 2012. J Immunol. 188:632. PubMed
  2. Elias S, et al. 2020. Haematologica. . PubMed
  3. Ward J, et al. 2007. Blood. 110:1207. PubMed
AB_571931 (BioLegend Cat. No. 317202)

Antigen Details

Type I transmembrane tyrosine-phosphorylated glycoprotein, CD2/CD150 subfamily, 60 kD

NK cells, T cells, B cells

CD28 independent T cell costimulation, induction of NK cell cytotoxicity, regulation of B cell tolerance
Cell Type
B cells, NK cells, T cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Bottino C, et al. 2001. J. Exp. Med. 194:235.
2. Valdez PA, et al. 2004. J. Bio. Chem. 279:18662.
3. Flaig RM, et al. 2004. J. Immunol. 172:6524.
4. Falco M, et al. 2004. Eur. J. Immunol. 34:1663.
5. Kumar KR, et al. 2006. Science 312:1665.

Gene ID
114836 View all products for this Gene ID
View information about CD352 on UniProt.org

Related FAQs

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Go To Top Version: 3    Revision Date: 05/03/2016

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD352 (NTB-A)

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  • TotalSeq™-A0864 anti-human CD352 (NTB-A)

  • TotalSeq™-C0864 anti-human CD352 (NTB-A)

  • Ultra-LEAF™ Purified anti-human CD352 (NTB-A)

  • TotalSeq™-B0864 anti-human CD352 (NTB-A) Antibody


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