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- Clone
- A16085C (See other available formats)
- Regulatory Status
- RUO
- Other Names
- VEGFR2, KDR
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
HUVEC human endothelial cells were stained with purified CD309 (clone A16085C) (filled histogram) or mouse IgG2b, κ isotype control (open histogram), followed by anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 392202 | 100 µg | $229 | ||||
CD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human VEGFR2-Fc Chimera
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2721740 (BioLegend Cat. No. 392202)
Antigen Details
- Structure
- Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1/PDGF receptor family.
- Distribution
-
Endothelial cells, embryonic tissues.
- Function
- VEGFR2 regulates angiogenesis as well as vascular development and permeability.
- Interaction
- VEGF-A, SHC2, NPR1, NCK1
- Ligand/Receptor
- VEGF-A, VEGF-C, and VEGF-D splice isoforms
- Cell Type
- Endothelial cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
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1. DiSalvo J, et al. 1995. J Biol Chem. 270:7717.
2. McColl BK, et al. 2003. J Exp Med. 198:863.
3. Albuquerque RJ, et al. 2009. Nat Med. 15:1023.
4. Guangqi E, et al. 2012. J Biol Chem. 287:3029.
5. Koch S, and Claesson-Welsh. 2012. Cold Spring Harb Perspect Med. 2:a006502.
6. Munaut C, et al. 2012. Plos One 7:e33475.
7. Wehland M, et al. 2013. Int J Mol. Sci. 14:9338. - Gene ID
- 3791 View all products for this Gene ID
- UniProt
- View information about CD309 on UniProt.org
Related FAQs
Other Formats
View All CD309 (VEGFR2) Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD309 (VEGFR2) | A16085C | FC |
| PE anti-human CD309 (VEGFR2) | A16085C | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD309 (VEGFR2)
HUVEC human endothelial cells were stained with purified CD3... -
PE anti-human CD309 (VEGFR2)
HUVEC human endothelial cells were stained with anti-human C...
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