Purified anti-human CD276 (B7-H3) Antibody

Pricing & Availability
MIH42 (See other available formats)
Regulatory Status
Other Names
Mouse IgG1, κ
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Human B7-H3 transfected P815 cells were stained with CD276 (clone MIH42) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • MIH42_PE_020811
    Human B7-H3 transfected P815 cells were stained with CD276 (clone MIH42) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
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351002 100 µg $253
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B7-H3, assigned as CD276, is a type I transmembrane protein and shares 20-27% amino acid identity with other B7 family members. Human B7-H3 has a single extracellular variable-type immunoglobulin (IgV)-IgC domain, a signature intracellular domain, and an additional isoform, known as 4Ig-B7-H3, containing nearly exact tandem duplication of the IgV-IgC domain and most likely caused by exon duplication. B7-H3 mRNA is broadly expressed in normal tissues whereas its protein expression is relatively rare. The expression of B7-H3 is induced on T cells, natural killer (NK) cells, and antigen-presenting cells (APCs), including dendritic cells (DCs) and macrophages. It can be upregulated during the maturation from monocytes to DCs, or during the interaction between DCs and regulatory T cells. B7-H3 has been shown to be a co-stimulatory molecule that inhibits T-cell responses. B7-H3 has also been identified to bind TLT-2 involved in the intracellular signaling pathway.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Reported Reactivity
African Green, Cynomolgus, Rhesus
Antibody Type
Host Species
Human B7-H3
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

AB_10717510 (BioLegend Cat. No. 351002)

Antigen Details

Type I transmembrane protein with extracellular variable-type immunoglobulin domain and intracellular domain

Dendritic cells, macrophages, natural killer cells, induced T cells

Involved in intracellular signaling pathway
Co-stimulator molecule inhibits T-cell response. Binds Trem like transcript 2 protein (TLT-2) to involve in intracellular signaling.
Trem like transcript 2 protein (TLT-2)
Cell Type
Dendritic cells, Macrophages, NK cells, T cells, Tregs
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Signal Transduction
Molecular Family
CD Molecules
Gene ID
80381 View all products for this Gene ID
View information about CD276 on UniProt.org

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Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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