- 51.1 (See other available formats)
- Other Names
- Mouse IgG2b, κ
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- Product Citations
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CD1d is a MHC-like, type I transmembrane protein, member of the CD1 family and the immunoglobulin superfamily. On the cell surface, CD1d forms a heterodimer with β2-microglobulin. CD1d is expressed by antigen-presenting cells such as B cells, monocytes/macrophages, dendritic cells, and some non-lymphoid cells. Cortical thymocytes express CD1d but the expression is lost in mature T cells. CD1d presents lipid antigens to iNKT cells analogous to MHC molecule presentation of peptides to T cells.Product Details
- Human, Cynomolgus
- Antibody Type
- Host Species
- Human CD1d-Fc fusion
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F, IP, Stim, WB - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported application (for the relevant formats) include: immunohistochemical staining of frozen tissue sections1, Western blotting1,2, and induction of IL-12 production by crosslinking of CD1d3.
(PubMed link indicates BioLegend citation)
- Exley M, et al. 2000. Immunology 100:37. (IHC, WB)
- Durante-Mangoni E, et al. 2004. J. Immunol. 173:2159. (WB)
- Yue SC, et al. 2005. P. Natl. Acad. Sci. USA 102:11811. (Stim)
AB_10641848 (BioLegend Cat. No. 350302)
- MHC-like, type I transmembrane protein, member of the CD1 family and the immunoglobulin superfamily
Expressed by cortical thymocytes, monocytes, macrophages, dendritic cells, B cells (highly expressed on marginal zone B cells in particular), and in some non-lymphoid cells
- Present lipid antigens to iNKT cells
- Ligand Receptor
- When loaded with a lipid, is recognized by the Vα14i TCR from iNKT cells
- Cell Type
- B cells, Dendritic cells, Macrophages, Monocytes, Thymocytes
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, MHC Antigens, TCRs
- Antigen References
1. Koch M, et al. 2005. Nat. Immunol. 6:819.
2. Liu X, et al. 2010. P. Natl. Acad. Sci. USA 107:13010.
3. Zeissig S, et al. 2010. J. Clin. Invest. 120:2889.
4. Teige A, et al. 2010. J. Immunol. 185:345.
- Gene ID
- 912 View all products for this Gene ID
- View information about CD1d on UniProt.org
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