Purified anti-human CD159c (NKG2C) Antibody

Pricing & Availability
Clone
S19005E (See other available formats)
Regulatory Status
RUO
Other Names
Killer Cell Lectin Like Receptor C2, KLRC2, NK Cell Receptor C
Isotype
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
publications
S19005E_PURE_CD159c_Antibody_042920.png
Human peripheral blood lymphocytes were stained with purified CD159c (NKG2C) (clone S19005E) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD3 Pacific Blue™.
  • S19005E_PURE_CD159c_Antibody_042920.png
    Human peripheral blood lymphocytes were stained with purified CD159c (NKG2C) (clone S19005E) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD3 Pacific Blue™.
Cat # Size Price Quantity Check Availability Save
375002 100 µg $352
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD159c, also known as NKG2C or KLRC2, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2C is an activating NK cell receptor and it is expressed as a heterodimer with CD94. In human, NKG2C/CD94 complex interacts HLA-E on target cells and delivers activating signals through immunoreceptor tyrosine-based activation motifs. 

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human NKG2C/CD94-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

S19005E does not crossreact with mouse CD159c.

RRID
AB_2888870 (BioLegend Cat. No. 375002)

Antigen Details

Structure
Type II transmembrane proteins of the C-type lectin superfamily
Distribution

NK cells, NKT cells, T cell subsets

Function
Activating NK cell receptor
Ligand/Receptor
HLA-E
Cell Type
Lymphocytes, NK cells, NKT cells, T cells
Biology Area
Immuno-Oncology, Immunology
Molecular Family
Immune Checkpoint Receptors
Antigen References
  1. Malisheni M, et al. 2017. Front Immunol. 8:863. 
  2. Sáez-Borderías A, et al. 2009. J Immunol, 182:829.
  3. Kamiya T, et al. 2019. J. Clin. Invest. 129:2094.
Gene ID
3822 View all products for this Gene ID
UniProt
View information about CD159c on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 04/29/2020

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD159c (NKG2C)

  • PE anti-human CD159c (NKG2C)

ProductsHere

Login/Register
Remember me
Forgot your password? Reset Password
Request an Account