Purified anti-human CD156c (ADAM10) Antibody

Pricing & Availability
SHM14 (See other available formats)
Regulatory Status
Other Names
MADM, KUZ, alpha-secretase
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes were stained with ADAM10 (SHM14) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • SHM14_PE_090111
    Human peripheral blood lymphocytes were stained with ADAM10 (SHM14) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
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352702 100 µg $206
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CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most cell types.  It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-α, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
Human A375 cell lines
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Lorenzen I, et al. 2016. Sci Rep. 6:35067. PubMed
  2. Vanderboom PM, et al. 2021. Cell Reports Methods. 1(3):. PubMed
  3. Künzel U et al. 2018. eLife. 7 pii: e35012. PubMed
AB_10897813 (BioLegend Cat. No. 352702)

Antigen Details

Consist of signal sequence, a N-terminal prodomain followed by a catalytic proteinase domain containing a zinc-binding motif, a disintegrin, cysteine-rich transmembrane, and a cytoplasmatic domain

Ubiquitously expressed on most of the cell types

Acts as an efficient α-secretase
Proteolysis the amyloid precursor protein (APP)
Cell Type
B cells, Dendritic cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Signal Transduction
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Edwards DR, et al. 2008. Mol. Aspects Med. 29:258.
2. Anders A, et al. 2001. FASEB J. 15:1837.
3. Endres K, et al. 2010. FEBS J. 277:1585.
4. Mochizuki S, et al. 2007. Cancer Sci. 98:621.

Gene ID
4684 View all products for this Gene ID
View information about CD156c on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 08/31/2022

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD156c (ADAM10)

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  • APC anti-human CD156c (ADAM10)


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