Purified anti-human CD143 (Angiotensin-converting enzyme) Antibody

Pricing & Availability
5-369 (See other available formats)
Other Names
ACE, kininase II, dipeptidyl dipeptidase 1, peptidase P, carboxycathepsin
Mouse IgG1, κ
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Product Citations
GM-CSF-stimulated human monocytes (day-3) stained with the 5-369 PE (gated in CD14+ cell population)
  • 5-369_PE_091509
    GM-CSF-stimulated human monocytes (day-3) stained with the 5-369 PE (gated in CD14+ cell population)
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344202 100 µg $120
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CD143 (ACE, kininase II, peptidyl dipeptidase 1, peptidase P, carboxycathepsin) is a 171 kD, type I, single chain transmembranal metallopeptidase, whose cofactor is zinc. Its main targets are angiotensin I and bradykinin, acting as a blood pressure regulator. CD143 is expressed in endothelial cells; varying amounts of CD143 have been reported in different epithelial cells. The activation of macrophages and histiocytes induces the expression of this molecule.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

AB_2222983 (BioLegend Cat. No. 344202)

Antigen Details

Single chain, type I transmembranal zinc metallopeptidase, 170 kD.

Endothelial cells, some types of epithelial cells, activated macrophages and histiocytes.

Regulates blood pressure by promoting vasoconstriction by the conversion of angiotensin I to angiotensin II and by the degradation of bradykinin, a vasodilator.
Angiotensin I, bradykinin.
Blood pressure regulator.
Cell Type
Endothelial cells, Epithelial cells, Macrophages
Biology Area
Molecular Family
CD Molecules
Antigen References

1. Nakamura T, et al. 2009. Int Heart J. 50:501.
2. Jayasooriya AP, et al. 2008. P. Natl. Acad. Sci. USA 105:6531.
3. Jokubaitis VJ, et al. 2008. Blood 111:4055.
4. Arndt PG, et al. 2006. J. Immunol. 177:7233.
5. Balyasnikova IV, et al. 2002. Biochem J. 362:585.

Gene ID
1636 View all products for this Gene ID
View information about CD143 on UniProt.org

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Go To Top Version: 1    Revision Date: 11/30/2012

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