- 13E11 (See other available formats)
- Other Names
- ACKR4, CC-CKR-11, VSHK1, PPR1, CCBP2, CCR10, CCR11, CKR-11, CCXCKR
- Mouse IgG2b, κ
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- Product Citations
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Human CCX-CKR, also known as CCRL1, is a 40 kD, G-protein-coupled, seven transmembrane receptor. CCRL1 is a decoy receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25 that regulates chemotaxis of lymphocytes and cancer cells. Chemokine binding by CCX-CKR causes its internalization, reducing levels of available chemokine, and thus regulating migration of lymphocytes and cancerous cells. CCX-CKR is expressed by stromal cells of skin-draining lymph nodes, thymic epithelial cells, and immature dendritic cells (DCs). A low CCX-CKR expression in tumor cells correlates with a poor survival rate of breast cancer patients.Product Details
- Antibody Type
- Host Species
- Full length CCX-CKR cDNA
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
ICC, IP, Agonist - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications for the relevant formats include: immunoprecipitation of CCX-CKR from cell lysates1, induction of CCX-CKR internalization1 and immunofluorescence1. 13E11 recognizes an epitope located within the first 14 amino acids of CCX-CKR.
(PubMed link indicates BioLegend citation)
- Takatsuka, S. et al. 2011. J. Pharmacol. Toxicol. Methods. 63:250. (IF, IP, Agonist)
- Product Citations
AB_2563201 (BioLegend Cat. No. 362102)
- G-protein-coupled seven transmembrane receptor, 40 kD.
Stromal cells of skin-draining lymph nodes, thymic epithelial cells, immature DCs.
- C-C type chemokine scavenger and decoy receptor, reduces chemokine availability by sequestering them inside the cell.
- Ligand Receptor
- CCL2, CCL8, CCL13, CCL19, CCL21, and CCL25.
- Cell Type
- Dendritic cells, Epithelial cells
- Biology Area
- Molecular Family
- Cytokine/Chemokine Receptors, GPCR
- Antigen References
1. Watts AO, et al. 2013. J. Biol. Chem. 288:7169.
2. Comerford I, et al. 2010. Blood. 116:4130.
- Gene ID
- 51554 View all products for this Gene ID
- View information about CCX-CKR (CCRL1) on UniProt.org
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