- W15090A (See other available formats)
- Other Names
- Histone deacetylase-like 1 (HDACL1), MRXS6, Wilson-Turner X-linked mental retardation syndrome (WTS), RPD3
- Mouse IgG1, κ
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- Product Citations
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Histone deacetylases (HDACs) are a family of enzymes responsible for the removal of acetyl groups from lysine residues on the core histones and other non-histone proteins. HDAC8 is a type I histone deacetylase and was initially found to deacetylate a variety of acetylated histone variants in vitro. HDAC8 is a kinectically and structurally well-characterized deacetylase that was reported to catalyze several nuclear proteins, which include ERR-α, hEST1B, and SMC3. Patients with HDAC8 mutations show Cornelia de Lange Syndrome (CdLS) and Wilson-turner Syndrome (WTS) phenotypes. Elevated expression of HDAC8 has been observed in various tumor types, such as acute lymphoblastic leukemia (AML), neuroblastomas, and glimoas. HDAC8 is implicated as a therapeutic target in cancer and infectious diseases.Product Details
- Antibody Type
- Host Species
- Full length human HDAC8 recombinant protein expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
KO/KD-WB, ICC - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2572204 (BioLegend Cat. No. 685502)
- 377 amino acids with a predicted molecular weight of 41.8 kD. It belongs to the type I Histone deacetylase subfamily.
Nucleus and cytoplasm.
- HDAC8 is a deacetylase and regulates gene expression through catalyzing the removal of acetyl groups on lysine residues in the core histones and transcriptional factors.
- Interacts with PEPB2-MYH11, CBFA2T3, SMG5, and alpha-SMA.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Neuroscience, Transcription Factors
- Antigen References
1. Qi J, et al. 2015. Cell Stem Cell. 17:597.
2. Tian Y, et al. 2015. Cancer Res. 75:4803.
3. Feng L, et al. 2015. J. Hum. Genet. 60:165.
4. Ha SD, et al. 2014. J. Immunol. 193:1333.
5. Higuchi T, et al. 2013. Blood 121:3640.
6. Deardorff MA, et al. 2012. Nature 489:313.
- Gene ID
- 55869 View all products for this Gene ID
- View information about HDAC8 on UniProt.org
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