Purified anti-Estrogen Receptor Antibody (Previously Covance catalog# SIG-3670)

Pricing & Availability
Clone
CO1531 (See other available formats)
Other Names
ESR, ESRA, ESTRR, Era, NR3A, Estrogen receptor beta, estrogen receptor beta 4, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, nuclear receptor subfamily 3 group A member 2
Previously
Signet Catalog# 670-01
Signet Catalog# 670-26 L2 Predilute
Covance Catalog# SIG-3670
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
CO1531_PURE_Estrogen_Antibody_060117
IHC staining of purified anti-Estrogen Receptor antibody (clone CO1531) on formalin-fixed paraffin-embedded human breast tumor tissue. Following antigen retrieval using Retrieve-All Antigen Unmasking System 1: Universal, 100X (Cat. No. 927901), the tissue was incubated with a 1:40 dilution of the primary antibody for 60 min at room temperature. BioLegend's Ultra-Streptavidin (USA) HRP kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • CO1531_PURE_Estrogen_Antibody_060117
    IHC staining of purified anti-Estrogen Receptor antibody (clone CO1531) on formalin-fixed paraffin-embedded human breast tumor tissue. Following antigen retrieval using Retrieve-All Antigen Unmasking System 1: Universal, 100X (Cat. No. 927901), the tissue was incubated with a 1:40 dilution of the primary antibody for 60 min at room temperature. BioLegend's Ultra-Streptavidin (USA) HRP kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
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916301 1 ml $422
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Description

Monoclonal Estrogen Receptor (ER) antibody clone CO1531 is directed against the beta form of estrogen receptor. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation.

Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution with BSA + 0.1% NaN3.
Preparation
The antibody was purified by affinity chromatography.
Storage & Handling
Store between 2°C and 8°C.
Application

IHC-P - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a dilution of 1:40 is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Schultz J, et al. 2002. J Biol Chem. 277: 8702.
RRID
AB_2565179 (BioLegend Cat. No. 916301)

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Go To Top Version: 3    Revision Date: 06/27/2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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