- 5B10 (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG2a
- Ave. Rating
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- Product Citations
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Caspase -1 plays a vital role in cleaving the inactive procytokine pro-IL-1 beta to generate the active 17 kd mature form of IL-1beta, a key mediator of inflammation. Active caspase-1 (ICE) is derived a single proenzyme of 45 Kd. An active ICE comprises two subunits of P20 and two subunits of P10 after removal a large amino-terminal pro-domain and a small linker peptide. Caspase-1 is reported to be involved in CD95- mediated apoptosis. Four alternatively spliced variants of caspase-1 have been reported, with mw ranging from 30-48 kd.Product Details
- Antibody Type
- Host Species
- Bacterial fusion protein (p20)
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1-2µg antibody per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Kang SJ, et al. 2000. J Cell Biol 149:613
- Kang SJ, et al. 2002. Cell Death and Differentiation. 9:1115
- Product Citations
AB_2068901 (BioLegend Cat. No. 645101)
AB_2068900 (BioLegend Cat. No. 645102)
- The whole length of Caspase-1 is a 404 amino acid polypeptide chain with MW of 45kd. The active Caspase -1 is a tetramer compariseing two subunits of 20Kd and 10Kd.
Predominantly in the cytoplasm, some localized to the external cell membrane.
- Caspase-1 is a mediator of the inflammatory response by cleaving the inactive pro-IL1 beta at Asp116/Ala 117 to generate the active 17k mature form of IL-1 beta.
- Pro-IL1 beta
- IL-1beta converting enzyme (ICE)
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Neuroscience
- Antigen References
1. Wilson KP et al. 1994. Nature 370:251
2. Cohen GM:1997 Biochem J 326:1
- Gene ID
- 834 View all products for this Gene ID
- View information about Caspase-1 on UniProt.org
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