- Poly8119 (See other available formats)
- Other Names
- Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Signet Catalog# 9148-005
Covance Catalog# SIG-39148
- Rabbit Polyclonal IgG
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- Product Citations
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APP intracellular domain (AICD) is a peptide fragment that results from intramembraneous proteolysis of the amyloid precursor protein (APP). APP is a single-pass transmembrane protein that is involved in the pathophysiology of Alzheimer's disease (AD). APP is cleaved by gamma-secretase that releases the AICD into the cytoplasm. Soon after its release from the membrane, AICD is rapidly degraded in the cytoplasm partly by insulin degrading enzymes.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution.
- The antibody was purified by affinity chromatography.
- 1.0 mg/ml
- Storage & Handling
- Do not store antibody diluted below 50 µg/mL in the absence of protein (i.e. add 2% bovine serum albumin). The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
ELISA, IHC, WB
IF - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay.
The optimal working dilution should be determined for each specific assay condition.
- Application Notes
This antibody is effective in immunohistochemistry (IHC), immunoblotting (WB), and ELISA.
This antibody is specific for AICD (APP intracellular domain), which is a peptide fragment that results from the cleavage of C83 or C99 at the epsilon site. It does not react with the C57 or C59 ?-secretase cleavage products of APP.
This product may contain other non-IgG subtypes.
(PubMed link indicates BioLegend citation)
- Kaori K, Yasushi K, Yasunari M, and Satoki U. Axonal Protection via Modulation of the Amyloidogenic Pathway in Tumor Necrosis Factor-Induced Optic Neuropathy. Invest. Ophthalmol. Vis. Sci.: 53, 7675 -7683, Nov 2012. (WB)
- Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, Barral JM, and Boehning D. Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein. J. Biol. Chem.: 256, 35689 -35698, Oct 2011. (WB)
- Tampellini D, Rahman N, Lin MT, Capetillo-Zarate E, and Gouras GK. Impaired ?-Amyloid Secretion in Alzheimer's Disease Pathogenesis. J. Neurosci.: 31, 15384 - 15390, Oct 2011. (IF) PubMed
- Product Citations
AB_2564761 (BioLegend Cat. No. 811901)
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