- SA271G2 (See other available formats)
- Regulatory Status
- Other Names
- Ms4a1, Ly-44
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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CD20 is a 33-37 kD protein, a member of the MS4A family, with four transmembrane spanning regions that present as a homo-oligomeric complexes in the cell surface when associating with MHC class I and II, CD53, CD81, and CD82. CD20 is expressed on B cells and a subset of T cells, but not on plasma cells. CD20 regulates B-cell activation and proliferation. Its ligation promotes transmembrane Ca2+ trafficking. CD20 is an important therapeutic target in the treatment of B cell lymphomas and leukemias.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse CD20 transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Bongard, A, et al. 2019. PLoS Pathog. 15(9):e1008043. (Depletion) Pubmed
AB_2890702 (BioLegend Cat. No. 152109)
AB_2890702 (BioLegend Cat. No. 152110)
- Member of the MS4A family, four transmembrane spanning regions, three isoforms of 37, 35, and 37 kD, depending on the phosphorylation degree.
B cells and a subset of T cells
- Regulates B-cell activation and proliferation
- Associates with MHC class I and II, CD53, CD81, and CD82
- Cell Type
- B cells, T cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Morsy DE, et al. 2013. J. Immunol. 191:3112.
2. Lund FE, Randall TD. 2010. Nat. Rev. Immunol. 10:236.
3.Beers SA, et al. 2010. Blood 115:5191.
4. Kuijpers TW, et al. 2010. J. Clin. Invest. 120:214.
- Gene ID
- 12482 View all products for this Gene ID
- View information about CD20 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD20 Reagents Request Custom Conjugation
|Purified anti-mouse CD20||SA271G2||FC,Depletion|
|Ultra-LEAF™ Purified anti-mouse CD20||SA271G2||FC,Depletion|
|PE anti-mouse CD20||SA271G2||FC|
|APC anti-mouse CD20||SA271G2||FC|
|PE/Dazzle™ 594 anti-mouse CD20 Antibody||SA271G2||FC|
|FITC anti-mouse CD20||SA271G2||FC|
|PE/Cyanine5 anti-mouse CD20||SA271G2||FC|
|APC/Fire™ 750 anti-mouse CD20||SA271G2||FC|
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