- QA20A52 (See other available formats)
- Regulatory Status
- Other Names
- IKZF2, IKAROS family zinc finger 2, ANF1A2, ZNF1A2, ZNFN1A2
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members. Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation of regulatory T cells. Helios plays an important role in T cell development and homeostasis. Overexpression of Helios profoundly alters αβ T cell differentiation and activation. It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function. Helios is also involved in tumor immunity.Product Details
- Verified Reactivity
- Mouse, Human
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone QA20A52 is able to completely block the staining of clone 22F6 on target cells
AB_2894413 (BioLegend Cat. No. 105403)
AB_2894413 (BioLegend Cat. No. 105404)
- A zinc finger nuclear transcription factor of the Ikaros family, containing 2 zinc-finger domains in C-terminal region.
Regulatory T cells (Tregs), conventional T cells, thymocytes.
- Plays an important role in T cell development and homeostasis, involved in tumor immunity.
- Cell Type
- T cells, Thymocytes, Tregs
- Biology Area
- Adaptive Immunity, Cell Biology, Immunology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
1. Kelly CM, et al. 1998. Curr Biol. 8:508.
2. Dovat S, et al. 2005. J Immunol. 175:3508.
3. Cortes M, et al. 1999. Curr Opin Immunol. 11:167.
4. Cai Q, et al. 2009. J Immunol. 183:2303.
5. Zhang Z, et al. 2007. Blood. 109:2190.
6. Hahm K, et al. 1998. Genes Dev. 12:782.
- Gene ID
- 22779 View all products for this Gene ID 22807 View all products for this Gene ID
- View information about Helios on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
|PE anti-mouse/human Helios Recombinant Antibody||QA20A52||ICFC|
|Purified anti-mouse/human Helios Recombinant Antibody||QA20A52||ICFC, Block|
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