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PE anti-mouse CD37 Antibody

Pricing & Availability
Clone
Duno85 (See other available formats)
Regulatory Status
RUO
Other Names
Tspan26, Tetraspanin-26
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
Dunno85_PE_CD37_Antibody_FC_1_070313
C57BL/6 mouse splenocytes were stained with CD45R/B220 APC and CD37 (clone Duno85) PE (top) or rat IgG2b, κ PE isotype control (bottom).
  • Dunno85_PE_CD37_Antibody_FC_1_070313
    C57BL/6 mouse splenocytes were stained with CD45R/B220 APC and CD37 (clone Duno85) PE (top) or rat IgG2b, κ PE isotype control (bottom).
  • Dunno85_PE_CD37_Antibody_FC_2_070313
See PE spectral data
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146203 25 µg $153
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146204 100 µg $360
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Description

CD37, also known as Tspan26 is a 40-60 kD member of the tetraspanin (TM4SF) family, with two extracellular regions and both termini in the cytoplasm. CD37 is highly expressed on mature B cells and is also expressed on T cells, monocytes, macrophages, and neutrophils, and dendritic cells to a lesser extent. CD37 forms complexes in the cell membrane with CD53, CD81, CD82, MHC class II and dectin 1. CD37 is essential for B cell survival, regulates T cell proliferation, IgA production, and is involved in dendritic cell migration. CD37 has been described as a promising target in the treatment of B cell malignancies.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Expression vector containing full length mouse CD37 gene
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2562285 (BioLegend Cat. No. 146203)
AB_2562286 (BioLegend Cat. No. 146204)

Antigen Details

Structure
Member of the tetraspanin (TM4SF) family, with two extracellular regions, both termini are cytoplasmic, 40-60 kD
Distribution
Highly expressed on B cells, low expression on T cells, monocytes, macrophages, neutrophils, and dendritic cells
Function
Essential for B cell survival, regulates T cell proliferation, regulates IgA production, involved in dendritic cell migration
Cell Type
B cells, Dendritic cells, Neutrophils
Biology Area
Immunology, Innate Immunity, Costimulatory Molecules
Molecular Family
CD Molecules
Antigen References

1. Gartlan KH, et al. 2013. Eur. J. Immunol. 43:1208.
2. Annemiek B, et al. 2012. Sci. Signal. 5:82.
3. van Spriel AB. 2011. Biochem. Soc. Trans. 39:512.
4. Heider, KH, et al. 2012. Blood 118:4159.

Gene ID
12493 View all products for this Gene ID
UniProt
View information about CD37 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 08/04/2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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