- 129C1 (See other available formats)
- Regulatory Status
- Other Names
- BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, PDCA-1
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD317, known as BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, or PDCA-1, is type II transmembrane glycoprotein with a molecular mass of 29-33 kD. It is predominantly expressed on Type I IFN-producing cells (IPCs) in naïve mice, but is up-regulated on most cell types following stimulation with type I IFNs and IFN-gamma. It is highly expressed on terminally differentiated normal plasmacytoid dendritic cells and some tumor cells, such as multiple myeloma, renal cell carcinoma, and melanoma cells. BST2 is a recently identified as IFN-induced cellular response factor that blocks release of HIV-1 and other retroviruses from infected cells. BST2 has been found to be the natural ligand of ILT7 in human model.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse plasmacytoid dendritic cells (DCs)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Blasius AL, et al. 2006. J. Immunol. 177:3260
- Kojima K, et al. 2011. Am J Respair Crit Care Med. 184:328. PubMed.
- Product Citations
AB_1953282 (BioLegend Cat. No. 127103)
AB_1953283 (BioLegend Cat. No. 127104)
- Type II transmembrane glycoprotein with a molecular mass of 29-33 kD.
Expressed on type I IFN-producing cells, plasmacytoid dendritic cells, and neoplastic B cells, such as multiple myeloma.
- Recently identified as antiviral protein that blocks the release of nascent retrovirus or other particles from infected cells.
- Cell Type
- Dendritic cells, B cells
- Biology Area
- Immunology, Innate Immunity, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Douglas JL, et al. 2009. J Virol. 83(16):7931
2. Cao W, et al. 2009. J. Exp. Med. 206(7):1603
3. Neil SJ, et al. 2008. Nature 451:425
- Gene ID
- 69550 View all products for this Gene ID
- View information about CD317 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
|Purified anti-mouse CD317 (BST2, PDCA-1)||129C1||FC, IP|
|PE anti-mouse CD317 (BST2, PDCA-1)||129C1||FC|
|Pacific Blue™ anti-mouse CD317 (BST2, PDCA-1)||129C1||FC|
|Alexa Fluor® 647 anti-mouse CD317 (BST2, PDCA-1)||129C1||FC|
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