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PE anti-mouse CD267 (TACI) Antibody

Pricing & Availability
Clone
8F10 (See other available formats)
Regulatory Status
RUO
Other Names
TACI
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
8F10_PE_042909.jpg
C57BL/6 splenocytes stained with 8F10 PE and RA3-6B2 APC
  • 8F10_PE_042909.jpg
    C57BL/6 splenocytes stained with 8F10 PE and RA3-6B2 APC
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133403 50 µg $98
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133404 200 µg $275
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Description

Transmembrane Activator and CAML Interactor (TACI) is a tumor necrosis factor receptor superfamily (TNFSF) member. It is a type III transmembrane protein sharing a high degree of homology with B cell maturation antigen (BCMA) among TNFSF members. It binds to the ligands BAFF (BLyS) and APRIL. CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity as well. The actual role for TACI in the mouse has still not been fully determined.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Rat RBL transfected cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Siegel RM, et al. 2001. Nat. Immunol. 2:577.
  2. Von Bulow GU, et al. 1997. Science 278:138.
  3. Yan M, et al. 2001. Nat. Immunol. 2:638.
  4. Diaz-de-Durana Y, et al. 2006. Blood 107:594.
  5. Moir S, et al. 2012. Blood. 120:4850. PubMed.
Product Citations
  1. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  2. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  3. Zhu H, et al. 2019. Nat Commun. 10:1084. PubMed
  4. Werner A, et al. 2021. iScience. 24:103076. PubMed
  5. Moir S, et al. 2012. Blood. 120:4850. PubMed
RRID
AB_2203542 (BioLegend Cat. No. 133403)
AB_2240584 (BioLegend Cat. No. 133404)

Antigen Details

Structure
TACI/CD267 is a type III transmembrane protein belonging to TNF receptor superfamily (TNFSF). Among TNFSF members, TACI shares a high degree of homology with B cell maturation antigen (BCMA). It binds to the ligands BAFF (BLyS) and APRIL.
Distribution

CD267 is expressed predominantly by splenic transitional type 2 and marginal zone B cells, as well as activated B cells. But it is notably absent from germinal center B cells.

Function
CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity.
Ligand/Receptor
BAFF (Blys/TALL-1/THANK) and APRIL
Cell Type
B cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Ng LG, et al. 2004. J. Immunology. 173:807.

Gene ID
57916 View all products for this Gene ID
UniProt
View information about CD267 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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