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PE anti-mouse CD192 (CCR2) Antibody

Pricing & Availability
Clone
SA203G11 (See other available formats)
Regulatory Status
RUO
Other Names
Ccr2, Ckr2, Ccr2a, Ccr2b
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
SA203G11_PE_CD192_Antibody_1_060716
C57BL/6 bone marrow was stained with Ly-6G APC, CD11b PE/Dazzle™ 594, and CD192 (clone SA203G11) PE (top) or rat IgG2b, κ PE isotype control (bottom). Dot plots are gated on Ly-6G- cells.
  • SA203G11_PE_CD192_Antibody_1_060716
    C57BL/6 bone marrow was stained with Ly-6G APC, CD11b PE/Dazzle™ 594, and CD192 (clone SA203G11) PE (top) or rat IgG2b, κ PE isotype control (bottom). Dot plots are gated on Ly-6G- cells.
  • SA203G11_PE_CD192_Antibody_2_060716
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
150609 25 µg $146
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150610 100 µg $365
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Description

CD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CCR2 transfectants.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Greferath U, et al. 2021. Front Cell Neurosci. 14:553708. PubMed
  2. Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed
  3. Samarchith P Kurup et al. 2019. Cell host & microbe. 25(4):565-577 . PubMed
  4. Aldrich AL, et al. 2021. The Journal of Immunology. 206(4):751-765. PubMed
  5. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  6. Li F, et al. 2019. Cancer Res. 79(15). PubMed
  7. Leylek R, et al. 2019. Cell Rep. 29:3736. PubMed
  8. Galle-Treger L, et al. 2020. J Allergy Clin Immunol. 145:502. PubMed
  9. Ben-Yehuda H, et al. 2021. Mol Neurodegener. 16:39. PubMed
  10. Laban H, et al. 2018. J Cell Biol. 217:1503. PubMed
  11. Nasser H, et al. 2020. Cell Death Discov. 0.29375. PubMed
  12. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  13. Schnoegl D, et al. 2022. Front Immunol. 13:909270. PubMed
  14. Bae S, et al. 2021. Cell Reports. 35(11):109264. PubMed
  15. Di Liberto G et al. 2018. Cell. 175(2):458-471 . PubMed
RRID
AB_2616981 (BioLegend Cat. No. 150609)
AB_2616982 (BioLegend Cat. No. 150610)

Antigen Details

Structure
G-protein-coupled receptor, 7-transmembrane protein, 42 kD.
Distribution

Monocytes/macrophages and basophils.

Function
Mediator of monocyte chemotaxis and bone marrow homeostasis.
Ligand/Receptor
MCP-1, Ccl2, Ccl7, and Ccl13.
Cell Type
Basophils, Macrophages, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Mack M, et al. 2001. J. Immunol. 166:4697.
2. Dutta P, et al. 2015. Cell Stem Cell. 16:477.
3. Li L, et al. 2008. Kidney Int. 74:1526.

Gene ID
12772 View all products for this Gene ID
UniProt
View information about CD192 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 06/09/2016

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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