- A16117B (See other available formats)
- Other Names
- MEK1, MAP2K1, CFC3, MKK1, MAPKK1, PRKMK1
- Mouse IgG1, κ
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- Product Citations
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MEK1 and MEK2 (Map/Erk Kinase) are serine/threonine kinases in the MAPK/ERK signaling axis that play a critical role in cellular proliferation, differentiation, and migration. Phosphorylation at MEK1 (Ser298) by PAK1 enhances the ability of upstream Raf kinases to phosphorylate regulatory serines (Ser218 and Ser222) in the activation loop, thereby stimulating kinase activity.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Human MEK1 peptide phosphorylated at Ser298. Complete Freund’s adjuvant.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2801109 (BioLegend Cat. No. 610603)
AB_2801110 (BioLegend Cat. No. 610604)
- MEK1 is a 393 amino acid protein with a predicted molecular weight of 43 kD
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Signal Transduction
- Molecular Family
- Phospho-Proteins, Protein Kinases/Phosphatase
- Antigen References
- Song C, et al. 2017. Sci Rep. 7:46833.
- Jeong DE, et al. 2017. EMBO J. 36:1046.
- Kyriakakis E, et al. 2017. Cell Signal. 35:163.
- Narbonne P, et al. PLoS Genet. 13:e1006738.
- Wu H, et al. 2013. PLoS One. 8:e83737.
- Wang Z, et al. 2010. Oncogene. 29:3362.
- Moniz S, et al. 2007. Oncogene. 26:6071.
- Park ER, et al. 2007. Cell Signal. 7:1488.
- Gene ID
- 5604 View all products for this Gene ID
- View information about MEK1 Phospho Ser298 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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