PE anti-human Notch 3 Antibody

Pricing & Availability
MHN3-21 (See other available formats)
Regulatory Status
Other Names
Neurogenic locus notch homolog protein 3, Notch-3, CADASIL
Mouse IgG1, κ
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Product Citations
Human T cell leukemia cell line HPB-ALL stained with MHN3-21 PE
  • MHN3-21_PE_112409
    Human T cell leukemia cell line HPB-ALL stained with MHN3-21 PE
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345405 25 tests $153
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345406 100 tests $335
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The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Human Notch 3-human IgG1 Fc fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Fermino M, et al. 2013. Eur J Immunol. 43:1806. PubMed
  2. Suliman S, et al. 2011. PLoS One. 6:e24937. PubMed
AB_2151232 (BioLegend Cat. No. 345405)
AB_2151231 (BioLegend Cat. No. 345406)

Antigen Details

Transmembrane receptor, heterodimer consisting of a C-terminal fragment and N-terminal fragment probably linked by disulphide bonds. Contains 5 ankyrin repeats, 29-36 EGF repeats, 3 Notch/Lin repeats.
Cell Type
Biology Area
Antigen References

1. Ehebauer ME. et al. 2006. Biochem J 392:13
2. Joutel A et al. 1996. Nature 383:707
3. Shimizu K et al. 2000. Mol Cell Biology 20:18
4. Tanigaki K et al. 2007. Nature Immunol 8:451
5. Bellavia D et al. 2008. 27:5092
6. Louvi A et al. Dev Neurosci. 2006. 28:5

Gene ID
4854 View all products for this Gene ID
View information about Notch3 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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