PE anti-human CXCR7 Antibody

Pricing & Availability
Clone
10D1-J16 (See other available formats)
Other Names
Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159, ACKR3
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
10D1-J16_PE_CXCR7_Antibody_FC_051115
CXCR7 transfected L1.2 cells were stained with CXCR7 (clone 10D1-J16) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
  • 10D1-J16_PE_CXCR7_Antibody_FC_051115
    CXCR7 transfected L1.2 cells were stained with CXCR7 (clone 10D1-J16) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
See PE spectral data
Cat # Size Price Quantity Avail. Save
391403 25 tests $125
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391404 100 tests $325
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Description

CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Doijen J, et al. 2017. PLoS One. 10.1371/journal.pone.0185354. PubMed
Publication Library
RRID
AB_2565680 (BioLegend Cat. No. 391403)
AB_2565681 (BioLegend Cat. No. 391404)

Antigen Details

Structure
G Protein-Coupled Receptor super family
Distribution
Monocytes, B cells, T cells, and mature dendritic cells.
Function
Regulates trafficking and activation of leukocytes.
Ligand/Receptor
CXCL12/SDF-1 and CXCL11/I-TAC.
Cell Type
Monocytes, B cells, T cells, Dendritic cells
Biology Area
Cell Biology, Immunology, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Torossian F, et al. 2014. Blood 123:191.
2. Walentowicz-Sadlecka M, et al. 2014. PLoS One 1:e84629.
3. Yates TJ, et al. 2013. Cancer 119:61.
4. Burns JM, et al. 2006. J. Exp. Med. 203:2201.
5. Infantino S, et al. 2006. J. Immunol. 176:2197.

Gene ID
57007 View all products for this Gene ID
UniProt
View information about CXCR7 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 05/12/2015

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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