PE anti-human CD317 (BST2, Tetherin) Antibody

Pricing & Availability
RS38E (See other available formats)
Regulatory Status
Other Names
BST2, Tetherin, HM1.24, Bone marrow stromal antigen 2
Mouse IgG1, κ
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Product Citations
Human peripheral blood monocytes stained with RS38E PE
  • RS38E_PE_051010
    Human peripheral blood monocytes stained with RS38E PE
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348405 25 tests $138
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348406 100 tests $325
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CD317, also known as BST2, Tetherin, and HM1.24, is a type II transmembrane GPI-protein with a molecular weight of about 29-33 kD. It is an interferon-induced protein expressed on dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells, and some non-hematopoietic cells. BST2 inhibits cytokine production through interaction with ILT7 (CD85g). It is also involved in the regulation of B cell growth. More importantly, BST2 has been found to restrict the release of a number of viruses from infected cells, including all tested retroviruses (such as HIV-1) and some arenaviruses and filoviruses. In HIV-1 studies, it has been reported that BST2 retains the nascent virons on the surface of infected cells by incorporation of the protein into HIV-1 particles. HIV-1 Vpu is able to induce BST2 degradation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human, African Green, Baboon, Cynomolgus, Pigtail, Rhesus Macaque
Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Ishikawa J, et al. 1995. Genomics 26:527.
  2. Miyagi E, et al. 2011. J. Virol. 85:11981. PubMed
  3. Yokoyama T, et al. 2013. Int. J. Cancer. 132: 472. (FC) PubMed
Product Citations
  1. Urata S, et al. 2018. PLoS Pathog. 14:e1007172. PubMed
  2. Naamati A, et al. 2019. Elife. 8:e41431. PubMed
  3. van Stigt Thans T, et al. 2020. Journal of Virology. 93(20):e00719-19.. PubMed
  4. Lau D, et al. 2011. J Virol. 85:9834. PubMed
  5. Fukuma A, et al. 2013. PLoS One. 8:61530.. PubMed
  6. Thippeshappa R, et al. 2013. J Virol. 87:6678. PubMed
  7. Hamilton J, et al. 2015. J Immunol. 194:5022. PubMed
  8. Martrus G, et al. 2016. J Virol. 90: 9018 - 9028. PubMed
  9. Ma T, et al. 2016. Sci Rep. 6:34752. PubMed
  10. Rai MA, et al. 2020. Retrovirology. 17:35. PubMed
  11. Soday L, et al. 2021. Frontiers in Immunology. 12:600056. PubMed
AB_10567247 (BioLegend Cat. No. 348405)
AB_10564402 (BioLegend Cat. No. 348406)

This product is manufactured and sold under a license and covered by a number of issued patents. Users who intend to file a patent relating to the use of this product or who intend to develop therapeutic use of this antibody are required to report to Biolegend in advance.

Antigen Details

Type II transmembrane, GPI-anchored protein, 29-33 kD

Dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells

Regulate B cell growth, inhibit cytokine production, retain progeny virons on the surface of infected cells
ILT7 (CD85g)
Cell Type
B cells, Dendritic cells, Granulocytes, Monocytes, NK cells, Plasma cells, T cells
Biology Area
Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Sugamata OT, et al. 1999. Biochem. Bioph. Res. Co. 258:583.
2. Neil SJ, et al. 2008. Nature 451:425.
3. Fitzpatrick K, et al. 2010. PLoS Pathog. 6:e1000701.
4. Azuma KS, et al. 2008. Cancer Sci. 99:2461.
5. Cao W, et al. 2009. J. Exp. Med. 206:1603.
6. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers.

Gene ID
684 View all products for this Gene ID
View information about CD317 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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