- 1H7/CD221 (See other available formats)
- Other Names
- Insulin-like growth factor 1 receptor (IGF1R)
- Mouse IgG1, κ
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- Product Citations
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CD221, also known as insulin-like growth factor 1 receptor (IGF1R), is a 135 kD transmembrane receptor. It is widely expressed on lymphoid and myeloid cells as well as non-haematopoietic cells. CD221 is a tyrosine kinase receptor and the ligands for CD221 are insulin-like growth factor 1 and 2 (IGF-1 and IGF-2), the polypeptide hormones similar in molecular structure to insulin. IGF-1/2 binding activates downstream PI3K and MAPK pathways and plays an important role in cell growth. Recent studies reveal its function of recruiting immune cells during tissue repair.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- IGF-1 receptor purified from human placentas
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
This clone has been published as 1H7. Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, immunohistochemical staining of frozen tissue sections2, and blocking functions2-5.
This product is offered for sale and sold pursuant to a license to seller by City of Hope and may be used only as a research reagent. Use for any other purpose is expressly not authorized.
(PubMed link indicates BioLegend citation)
- Li SL, et al. 1993. Biochem. Bioph. Res. Co. 196:92. (WB IP)
- Li SL, et al. 2000. Cancer Immunol. Immun. 49:243. (IHC Block)
- Ye JJ, et al. 2003. Horm. Metab. Res. 35:836. (Block)
- Kusada Y, et al. 2008. J. Biochem. 143:9. (Block)
- Ohtani M, et al. 2009. Biosci. Trends. 3:131. (Block)
- Product Citations
AB_10900986 (BioLegend Cat. No. 351805)
AB_10895918 (BioLegend Cat. No. 351806)
- IGF-1R contains 2 α subunits and 2 β subunits, 135 kD
Haematopoietic cells and non-haematopoietic cells
- Cell growth and immune cells recruitment
- IGF-1, IGF-2
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Baudler S, et al. 2005. J. Immunol. 174:5516.
2. Sharp LL, et al. 2005. Nat. Immunol. 6:73.
- Gene ID
- 3480 View all products for this Gene ID
- View information about CD221 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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