- UP-R1 (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 14 polymorphic KIR genes have been reported in humans. CD158f is a 60 kD glycoprotein with 2 Ig-like extracellular domains and long cytoplasmic domains. Its expression is highly polymorphic between individuals and mainly expressed on a subset of NK cells and a small population of T cells. HLA class I alleles are the ligands of CD158f.Product Details
- Antibody Type
- Host Species
- Human KIR2DL5-Ig fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Estefania E, et al. 2007. J. Immunol. 178:4402
- Product Citations
AB_1595545 (BioLegend Cat. No. 341303)
AB_2130701 (BioLegend Cat. No. 341304)
- Contains two Ig-like extracellular domains, 60 kD
Subset of NK cells and a small subset of T cells, polymorphic expression
- Inhibits NK cell function, play a role in self-tolerance.
- HLA alleles
- Cell Type
- NK cells, T cells
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Gonzalez A, et al. 2008. Tissue Antigens. 72:11
- Gene ID
- 57292 View all products for this Gene ID
- View information about CD158f on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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