- QA16A01 (See other available formats)
- Regulatory Status
- Other Names
- Toll-like receptor 2, TLR-2, TIL4, CD282, TLR2
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD282 (Toll-like receptor 2, TLR2) is an 85kDa, type I transmembrane protein, with 14 leucine-rich repeats (LRR) in the extracellular domain and a toll/IL-1R (TIR) in the cytoplasmic region. TLR2 is expressed by monocytes/macrophages, dendritic cells, granulocytes, endothelial cell and epithelial cells. TLR2 associates with TLR1 and TLR6 in the cell surface and is involved in the recognition of pathogen-associated molecular patterns (PAMPs) such as peptidoglycan, lipoteihoic acid (LTA), lipoarabinomanan, lipoproteins, and LPS from certain Gram-negative bacteria, yeast, spirochete and fungi.Product Details
- Verified Reactivity
- Mouse, Human
- Antibody Type
- Host Species
- Recombinant extracellular domain of murine TLR2
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* KIRAVIA Blue 520™ has an excitation maximum of 495 nm, and a maximum emission of 520 nm.
KIRAVIA Blue™ 520 is a trademark of Sony. This product is subject to proprietary rights of Sony and is made and sold under license from Sony Corporation. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Sony and the Sony logo are registered trademarks of Sony Corporation.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
Blocking of IL-6 and TNF-a production induced by P3CSK4 on RAW264.7 cells was observed during development.
AB_2894420 (BioLegend Cat. No. 153009)
AB_2894420 (BioLegend Cat. No. 153010)
- Type I transmembrane protein, 14 leucine-rich repeats (LRR) in the extracellular domain, the intracellular domain contains a toll/IL-1R (TIR) domain.
Monocytes/macrophages, dendritic cells, granulocytes, endothelial cell, epithelial cells.
- Activates innate host defense, induces production of pro-inflammatory cytokines.
- TLR1, TLR6 , MYD88 and TRAF6.
- Peptidoglycan, lipoteihoic acid (LTA), lipoarabinomanan, lipoproteins, as well as different LPS from certain Gram-negative bacteria, yeast, spirochete and fungi.
- Cell Type
- Dendritic cells, Endothelial cells, Epithelial cells, Granulocytes, Macrophages, Monocytes, Neutrophils
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
1. Biswas S, et al. 2016. Blood. 127:2618.
2. Wang Y, et al. 2016. Proc. Natl. Acad. Sci. USA 113:884.
3. Ramstead AG, et al. 2016. Infect. Immun. 84:940.
4. Scheeren FA, et al. 2014. Nat. Cell. Biol. 16:1238.
5. Barbalat R, et al. 2009. Nat. Immunol. 10:1200.
- Gene ID
- 24088 View all products for this Gene ID 7097 View all products for this Gene ID
- View information about CD282 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD282 Reagents Request Custom Conjugation
|Ultra-LEAF™ Purified anti-mouse/human CD282 (TLR2) Recombinant Antibody||QA16A01||FC,Block|
|APC anti-mouse/human CD282 (TLR2) Recombinant Antibody||QA16A01||FC|
|Alexa Fluor® 647 anti-mouse/human CD282 (TLR2) Recombinant Antibody||QA16A01||FC|
|PE anti-mouse/human CD282 (TLR2) Recombinant Antibody||QA16A01||FC|
|KIRAVIA Blue 520™ anti-mouse/human CD282 (TLR2) Recombinant Antibody||QA16A01||FC|
|PE/Cyanine7 anti-mouse/human CD282 (TLR2) Recombinant Antibody||QA16A01||FC|
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Ultra-LEAF™ Purified anti-mouse/human CD282 (TLR2) Recombinant Antibody
APC anti-mouse/human CD282 (TLR2) Recombinant Antibody
Alexa Fluor® 647 anti-mouse/human CD282 (TLR2) Recombinant Antibody
PE anti-mouse/human CD282 (TLR2) Recombinant Antibody
KIRAVIA Blue 520™ anti-mouse/human CD282 (TLR2) Recombinant Antibody
PE/Cyanine7 anti-mouse/human CD282 (TLR2) Recombinant Antibody