- 2M2 (See other available formats)
- Regulatory Status
- Other Names
- β2M, β2-M, beta2-microglobulin b2-M, b2M
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus, Swine (Pig, Porcine)
- Antibody Type
- Host Species
- Purified human β2-microglobulin
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
ELISA Detection - Quality tested
FC - Verified
- Recommended Usage
Dilute 18 µl of HRP anti-human β2-microglobulin antibody in 12 ml of assay dilution buffer. This is sufficient for one 96 well plate.
- Application Notes
Additional reported applications (for the relevant formats) include: Western blotting, and ELISA.
(PubMed link indicates BioLegend citation)
AB_2617014 (BioLegend Cat. No. 280303)
- Nonpolymorphic Ig like structure, noncovalently associated with heavy chain of MHC class I molecules, 12 kD
- Leukocytes, platelets, endothelial cells, epithelial cells
- Govern MHC class I molecule stability, promote MHC class I molecules binding and presenting peptide antigens to CD8+ T cells
- CD3/TCR complex, CD8
- Cell Type
- Leukocytes, Platelets, Endothelial cells, Epithelial cells
- Biology Area
- Molecular Family
- MHC Antigens
- Antigen References
1. Engelhard VH. 1994. Curr. Opin. Immunol. 6:13.
2. Williams DB, et al. 1989. J. Immunol. 142:2796.
3. Danliczyk UG and TL. Delovitch. 1994. J. Immunol. 153:3533.
4. Williams A, et al. 2002. Tissue Antigens 59:3.
- Gene ID
- 567 View all products for this Gene ID
- View information about beta2-microglobulin on UniProt.org
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