- A15113A (See other available formats)
- Other Names
- Apolipoprotein J, Apo-J, Complement cytolysis inhibitor, Aging-associated gene 4 protein, Complement-associated protein SP-40,40, Ku70-binding protein 1, NA1/NA2 TRPM-2
- Mouse IgG2a, κ
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- Product Citations
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Clusterin, also known as Apolipoprotein J, is a heterodimeric glycoprotein that is a member of the heat-shock protein family. The protein exhibits a wide array of biological functions including clearance of cellular debris through chaperone activity, apoptosis, lipid transportation, cell clustering, and complement inhibition. Clusterin is involved in many diseases related to oxidative stress and aging, including neurodegenerative disorders, cancers, diabetes, and inflammatory diseases.Product Details
- Antibody Type
- Host Species
- Recombinant human clusterin.
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 – 1.0 µg per ml. For immunohistochemistry, a concentration range of 1.0 – 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2728569 (BioLegend Cat. No. 848703)
AB_2728570 (BioLegend Cat. No. 848704)
- Clusterin is a protein of 449 amino acids with a molecular mass of 52 kD.
Tissue distribution: Ubiquitously expressed.
Cellular distribution: Primarily extracellular in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Intracellular clusterin is primarily present in the endoplasmic reticulum, cytosol, mitochondrion, and nucleus.
- Clusterin is involved in several biological processes including extra- and intracellular chaperone activity, pro- and anti-apoptotic properties, lipid transportation, cell clustering, modulation of NF-kappa-B transcriptional activity, and complement inhibition.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Complement, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Antigen References
1. Trougakos IP. 2013. Gerontology 59:514. PubMed
2. Rizzi F, Bettuzzi S. 2010. Endocr. Relat. Cancer 17:R1. PubMed
3. Desikan RS, et al. 2014. JAMA Neurol. 71:180. PubMed
4. Carver JA, et al. 2003. IUBMB Life. 55:661. PubMed
- Gene ID
- 1191 View all products for this Gene ID
- View information about Clusterin on UniProt.org
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