- 11A50-B10 (See other available formats)
- Other Names
- AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Signet Catalog# 9146-02
Covance Catalog# SIG-39146
- Mouse IgG1
- Ave. Rating
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- Product Citations
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Amyloid beta (Aβ or Abeta) denotes peptides of 36-43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds") which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.Product Details
- Antibody Type
- Host Species
- Aqueous buffered solution containing a carrier protein and preservatives.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store between 2-8°C. Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin).
ELISA, WB, IHC, IP
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay.
The optimal working dilution should be determined for each specific assay condition.
- Application Notes
This antibody is effective in ELISA, immunoblotting (WB), immunohistochemistry (IHC) and immunoprecipitation (IP).
This antibody is reactive to the c-terminus of beta amyloid and specific for the isoform ending at the 40th amino acid.
(PubMed link indicates BioLegend citation)
- Watts JC, et al. 2014. Proc. Natl. Sci. USA 28:10323. (IHC-P) PubMed
- Diomede L, et al. 2014. Neurobiol. Dis. 62:521. (Dot Plot) PubMed
- Watanabe H, et al. 2012. J Neurosci. 15:5085. (ELISA) PubMed
- Portelius E, et al. 2006. J. Proteome Res. 4:1010. (IP)
- Vingtdeux V, et al. 2011. FASEB J. 25:219. (ELISA) PubMed
- Ohmi K, et al. 2011. PLoS One 11:e27461. (IHC-Other) PubMed
- Product Citations
AB_2564979 (BioLegend Cat. No. 805407)
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Gene ID
- 351 View all products for this Gene ID
- View information about beta-Amyloid, x-40 on UniProt.org
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