- Syn-O2 (See other available formats)
- Other Names
- Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-amyloid beta component (NAP)
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- Product Citations
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α-synuclein is expressed principally in the nervous system, but it is also produced in the other tissues, including the skin. In the brain, the protein is primarily neuronal, but it is also present in glia. Neuronal α-synuclein is concentrated in the presynaptic nerve terminals, interacts with plasma membrane phospholipids, and is also present in the nuclei and mitochondria. At least three isoforms of synuclein are produced through alternative splicing. The most common isoform is a 140 amino acid-long transcript. Other isoforms are α-synuclein-126, lacking residues 41-54; and α-synuclein-112, which lacks residues 103-130. α-synuclein’s physiological role is poorly understood, but the protein has been implicated in regulating dopamine release and transport, synaptic vesicle clustering, and functioning as a SNARE-complex chaperone. α-Synuclein fibrils are a major component of the intracellular Lewy bodies that are associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy.Product Details
- Antibody Type
- Host Species
- Aggregated α-synuclein
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone does not cross-react with β- or γ-synucleins using Dot Blot as detection method.
(PubMed link indicates BioLegend citation)
- Majbour NK, et al. 2016. Mol. Neurodegener. 11:7. (IHC, ELISA Capture, Dot Blot)
- Vaikath NN, et al. 2015. Neurobiol Dis. 79:81. (IHC, ELISA Capture, Dot Blot)
AB_2734620 (BioLegend Cat. No. 847603)
AB_2734621 (BioLegend Cat. No. 847604)
- α-synuclein's canonical isoform consists of 140 amino acids, which consists of four 11-residue repeats containing the consensus sequence KTKEGV. While, α-synuclei has an apparent molecular mass of 14 kD.
Cellular distribution: Cytoskeleton, cytosol, lysosome, mitochondria, nucleus, plasma membrane, and extraceullar.
Tissue distribution: Primarily in the nervous system, but is lower expressed in other tissues.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Antigen References
1. Mor DE, et al. 2016. Neurobiol. Dis. 88:66.
2. Jucker M, Walker LC. 2013. Nature. 501(7465):45.
3. Bartels T, et al. 2011. Nature. 477(7362):107.
4. Devine MJ, et al. 2011. Mov. Disord. 26:2160.
- Gene ID
- 6622 View all products for this Gene ID
- View information about alpha-Synuclein, aggregated on UniProt.org
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