HRP anti-α-Synuclein, 103-108 Antibody

Pricing & Availability
4B12/Synuclein (See other available formats)
Regulatory Status
Other Names
NACP, PARK1, PARK4, PD1, Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-A beta component of AD amyloid Parkinson disease
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
Western blot of HRP anti-α-Synuclein, 103-108 (clone 4B12/Synuclein). Lane 1: Molecular weight marker; Lane 2: 10 µg of human brain lysate. The blot was incubated with 1 µg/mL of the primary antibody overnight at 4°C. Enhanced chemiluminescence was used as the detection system.
  • 1_4B12-Synuclein_HRP_alpha-Synuclein_Antibody_WB_072417
    Western blot of HRP anti-α-Synuclein, 103-108 (clone 4B12/Synuclein). Lane 1: Molecular weight marker; Lane 2: 10 µg of human brain lysate. The blot was incubated with 1 µg/mL of the primary antibody overnight at 4°C. Enhanced chemiluminescence was used as the detection system.
  • 2_4B12Synuclein_HRP_alpha-Synuclein_Antibody_IHC_011018
    IHC staining of HRP anti-α-Synuclein, 103-108 (clone 4B12/Synuclein) on formalin-fixed paraffin-embedded normal human (left) and Parkinson’s disease (right) brain tissue. After antigen retrieval using 70% formic acid, the tissues were incubated with 2.5 µg/mL of the primary antibody at for 24 hours at 4°C. DAB was used for detection followed by hematoxylin and bluing solution counterstaining, according to the protocol provided.
Compare all formats
Cat # Size Price Quantity Check Availability Save
807806 100 µg $297
Check Availability

Need larger quantities of this item?
Request Bulk Quote

α-Synuclein is expressed principally in the nervous system, but it is also produced in other tissues, including  the skin. In the brain, the protein is primarily neuronal, but it is also present in glia. Neuronal α-synuclein is concentrated in presynaptic nerve terminals, interacts with plasma membrane phospholipids, and is also present in nuclei and mitochondria. At least three isoforms of synuclein are produced through alternative splicing. The most common isoform is a 140 amino acid-long transcript. Other isoforms are a-synuclein-126, lacking residues 41-54; and α-synuclein-112, which lacks residues 103-130. α-Synuclein’s physiological role is poorly understood, but the protein has been implicated in regulating dopamine release and transport, synaptic vesicle clustering, and functioning as a SNARE-complex chaperone. α-Synuclein fibrils are major component of the intracellular Lewy bodies that are associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
This antibody was developed using a purified, E. coli produced human α-synuclein.
This antibody is provided in 50% glycerol in aqueous buffered solution with preservatives.
The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
0.5 mg/ml
Storage & Handling
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

IHC-P - Quality tested
WB - Verified

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody reacts with human a-synuclein. It does not react with mouse or rat a-synuclein. The epitope lies within amino acids 103-108 of a-synuclein.

Additional reported applications (for the relevant formats) include: ELISA2, Western blotting1,2,3,4,6,8, and immunoprecipitation4.

Application References

(PubMed link indicates BioLegend citation)
  1. Lahut S, et al. 2017. Dis Model Mech(WB) PubMed
  2. Landeck N, et al. 2016. Mol Neurodegener. 11(1): 61. (ELISA, WB) PubMed
  3. Moussaud S, et al. 2015. Expert Opin Ther Targets. 19(5): 589. (WB) PubMed
  4. Helferich AM., et al. 2015. Mol Neurodegener. 10(1): 66. (IHC, IP, WB) PubMed
  5. Bodis‐Wollner I, et al. 2014. Ann Neurol. 75(6): 964. (IHC)
  6. Shen W, et al. 2014. J Neurochem. 129(5): 884. (WB)
  7. Fagerqvist T, et al. 2013. J Neurochem. 126(1): 131. (IHC)
  8. Ebrahimi-Fakhari D, et al. 2011. J Neurosci. 31(41): 14508. (WB) PubMed
  9. Welander H, et al. 2011. Biochem Biophys Res Commun. 412(1): 32. (IHC)
AB_2721332 (BioLegend Cat. No. 807806)

Antigen Details

α-Synuclein’s canonical isoform is a 140 amino acid protein with an apparent molecular mass of 14 kD.

Tissue distribution: Primarily nervous system, but lower expression in other tissues.
Cellular distribution: Cytoskeleton, cytosol, lysosome, mitochondria, nucleus, plasma membrane, and extracellular.

Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
Antigen References
  1. Lee JM, et al. 2017. J Neuropathol Exp Neurol. 76(1):2.
  2. Kang SS, et al. 2017. Proc Natl Acad Sci. 114(5): 1183.
  3. Valdes P, et al. 2016. Front Neuroanat. 10:123.
  4. Emamzadeh FN. 2016. J Res Med Sci. 9(21):29.
Gene ID
6622 View all products for this Gene ID
View information about α-Synuclein, 103-108 on

Related FAQs

There are no FAQs for this product.

Other Formats

View All α-Synuclein, 103-108 Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-α-Synuclein, 103-108 4B12/Synuclein IHC-P, ELISA, WB
HRP anti-α-Synuclein, 103-108 4B12/Synuclein IHC-P, WB
Biotin anti-α-Synuclein, 103-108 4B12/Synuclein IHC-P, ELISA Detection, WB
Go To Top Version: 3    Revision Date: 08/28/2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


8999 BioLegend Way, San Diego, CA 92121
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-α-Synuclein, 103-108

  • HRP anti-α-Synuclein, 103-108

  • Biotin anti-α-Synuclein, 103-108


Remember me
Forgot your password? Reset Password
Request an Account