- TX25 (See other available formats)
- Regulatory Status
- Other Names
- DNAM-1, PTA1, TLiSA1
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-set. The ligands for CD226 are the poliovirus receptor (CD155) and its family member nectin-2 (CD112), which are broadly expressed on epithelial, endothelial and neuronal cells. CD226 is physically associated with LFA-1 in NK cells and activated T cells, and involved in LFA-1-mediated signaling.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
AB_1236399 (BioLegend Cat. No. 337104)
- Ig domain containing adhesion molecule
Peripheral blood T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells.
- Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
- Interacts with LFA-1.
- PVR (CD155) and Nectin-2 (CD112)
- Cell Type
- B cells, Macrophages, Megakaryocytes, Monocytes, NK cells, Platelets, T cells
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Shibuya A et al. 1996. Immunity 4:573.
2. Tahara-Hanaoka S et al. 2004. Int. Immunol. 16:533.
3. Pende D et al. 2005. Mol. Immunol. 42:463.
- Gene ID
- 10666 View all products for this Gene ID
- View information about CD226 on UniProt.org
|PE anti-human CD226 (DNAM-1)||TX25||FC|
|FITC anti-human CD226 (DNAM-1)||TX25||FC|
|Purified anti-human CD226 (DNAM-1)||TX25||FC|
|TotalSeq™-A0805 anti-human CD226 (DNAM-1)||TX25||PG|
|TotalSeq™-C0805 anti-human CD226 (DNAM-1)||TX25||PG|
|TotalSeq™-D0805 anti-human CD226 (DNAM-1) Antibody||TX25||PG|
|TotalSeq™-B0805 anti-human CD226 (DNAM-1)||TX25||PG|
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