FITC anti-human CD172a/b (SIRPα/β) Antibody

Pricing & Availability
148 (See other available formats)
Regulatory Status
Other Names
SIRPa, SIRPb, SIRPalpha/beta, BIT, SHPS1, MFR, P84, PTPNS1, CD172 antigen-like family member A, CD172 antigen-like family member B
Mouse IgG1, κ
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Product Citations
Human peripheral blood granulocytes stained with 148 FITC
  • 148_FITC_110308.jpg
    Human peripheral blood granulocytes stained with 148 FITC
See FITC spectral data
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337304 100 tests $229
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SIRPs (signal-regulatory proteins) are a family of transmembrane glycoproteins that belong to Ig superfamily. SIRPa (CD172a, SIRPb),(SIRPb1,CD172b), and SIRPg (SIRPb2,CD172g) have been described. CD172a/b molecules are expressed on myeloid cells and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration. CD47 (IAP) is an extracellular ligand for CD172a. CD172b is a disulfide-linked homodimer. CD172b has been shown to regulate neutrophil transepithelial migration through the interaction with DAP12 and Syk kinase (through TYROBP).

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications include: mAb 148 is specific for CD172a/b, and also stains CD172g transfected cells, but not T-lymphocytes

Application References

(PubMed link indicates BioLegend citation)
  1. Piccio L, et al. 2005. Blood 105:2421
  2. Dietrich J, et al. 2000. J. Immunol. 164:9
Product Citations
  1. Connor SM, et al. 2022. Front Cell Neurosci. 16:894601. PubMed
AB_2254620 (BioLegend Cat. No. 337304)

Antigen Details

Signal-regulatory-protein family, Ig superfamily

Monocytes/macrophages, granulocytes, dendritic cells, neurons

CD172a binds CD47, CD172b interacts with DAP12
Cell Type
Dendritic cells, Granulocytes, Macrophages, Monocytes, Neurons
Biology Area
Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References

1. Kharitonenkov A, et al. 1997. Nature 386:181.
2. Tomasello E, et al. 2000. Eur. J. Immunol. 30:2147.
3. Seiffert M, et al. 2001. Blood 97:2741.
4. Timms JF, et al. 1998. Mol. Cell Biol. 18:3838.
5. Barclay AN and MH. Brown. 2006. Nat. Rev.Immnuol. 6:457

Gene ID
10326 View all products for this Gene ID 140885 View all products for this Gene ID
View information about CD172alpha/beta on

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Go To Top Version: 2    Revision Date: 10/25/2016

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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  • FITC anti-human CD172a/b (SIRPα/β)


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