FITC anti-human CD105 Antibody

Pricing & Availability
Clone
43A3 (See other available formats)
Other Names
Endoglin
Isotype
Mouse IgG1, κ
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Product Citations
publications
43A3_FITC_050707
Human monocytic cell line THP-1 stained with 43A3 FITC
  • 43A3_FITC_050707
    Human monocytic cell line THP-1 stained with 43A3 FITC
See FITC spectral data
Cat # Size Price Quantity Avail. Save
323203 25 tests $75
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323204 100 tests $145
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Description

CD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and β3 with high affinity but does not bind to TGF-β2.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
L-cells transfected with human CD105
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Bühring HJ, et al. 1991. Leukemia 5:841.
  2. Vogel W, et al. 2002. Haematologica 88:126.
  3. Osaka M, et al. 2011. Brain Res. 9:1343. PubMed
  4. HonMou O, et al. 2011. Brain. 134:1790. PubMed
  5. Herrera MB, et al. 2013. Hepatology. 57:311. PubMed
  6. Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed
Product Citations
  1. Zhang X, et al. 2010. Exp Biol Med. 235:1505. PubMed
  2. Oeztuerk-Winder F, et al. 2012. EMBO J. 31:3431. PubMed
  3. Ishizaka R, et al. 2012. Biomaterials. 33:2109. PubMed
  4. Grisendi G, et al. 2010. Cytotherapy. 12:466. PubMed
  5. Okochi M, et al. 2008. Biochem Biophys Res Commun. 371:85. PubMed
  6. Aomatsu E, et al. 2014. Sci Rep. 4:3652. PubMed
  7. Uezumi A, al < 2014. Cell Death Dis. 5:1186. PubMed
  8. Jin J, et al. 2014. J Biosci Bioeng. 118:593. PubMed
  9. Nodomi S, et al. 2016. Oncogene. 10.1038/onc.2016.72. PubMed
  10. Khan M, et al. 2016. PLoS One. 11:e0165718. PubMed
  11. Motedayyen H, et al. 2017. BMC Res Notes. . 10.1186/s13104-017-2880-6. PubMed
  12. Liu Y, et al. 2018. Chin J Cancer. 37:2. PubMed
  13. Liu Z, et al. 2018. Cancer Med. 10.1002/cam4.1584. PubMed
  14. Sprouse ML, et al. 2019. Int J Mol Sci. 20:8. PubMed
Publication Library
RRID
AB_755955 (BioLegend Cat. No. 323203)
AB_755956 (BioLegend Cat. No. 323204)

Antigen Details

Structure
Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD
Distribution

Endothelial cells, activated monocytes/macrophages, bone marrow stromal cells, hematopoietic stem/progenitor cells

Function
Modulates cellular response to TGF-ß, involved in vascular development and remodelling
Ligand/Receptor
TGF-ß1, TGF-ß3
Cell Type
Endothelial cells, Monocytes, Macrophages, Hematopoietic stem and progenitors, Mesenchymal Stem Cells
Biology Area
Angiogenesis, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Mason D, et al. Eds. 2002. Leucocyte Typing VII. Oxford University Press. New York.
2. Pierelli L, et al. 2001. Leuk. Lymphoma 42:1195.

Gene ID
2022 View all products for this Gene ID
UniProt
View information about CD105 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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