Biotin anti-mouse Ly-49A Antibody

Pricing & Availability
YE1/48.10.6 (See other available formats)
Regulatory Status
Other Names
Klra1, A1, killer cell lectin-like receptor, subfamily A, member 1
Rat IgG2a, κ
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Product Citations
C57BL/6 mouse splenocytes stained with YE1/48.10.6 PE and DX5 FITC
  • YE1/48.10.6
    C57BL/6 mouse splenocytes stained with YE1/48.10.6 PE and DX5 FITC
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116803 50 µg $70.00
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Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Dd and H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
Con A activated splenic T cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2


Application References

(PubMed link indicates BioLegend citation)
  1. Takei F. 1983. J. Immunol. 130:2794.
  2. Chan P, et al. 1989. J. Immunol. 142:1727.
Product Citations
  1. Brodin P, et al. 2010. PLoS One. 5:e13174. PubMed
  2. Pyzik M, et al. 2011. J Exp Med . 208:1105. PubMed
  3. Brodin P, et al. 2012. J Immunol. 188:2218. PubMed
AB_313754 (BioLegend Cat. No. 116803)

Antigen Details

C-type lectin, Ly-49, ITIM, 44 kD

NK and NK-T cells

Inhibitory NK cell receptor
MHC Class I Molecules
Cell Type
NK cells, NKT cells
Biology Area
Antigen References

1. Coles MC, et al. 2000. Eur. J. Immunol. 30:236.
2. Takei FJ, et al. 1997. Immunol. Rev. 155:67.
3. Hanke T, et al. 1999. Immunity 11:67.

Gene ID
16627 View all products for this Gene ID
View information about Ly-49A on

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 1    Revision Date: 11/30/2012

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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