Biotin anti-human IgG Fc Antibody

Pricing & Availability
M1310G05 (See other available formats)
Regulatory Status
Rat IgG2a, κ
Ave. Rating
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Product Citations
Human peripheral blood lymphocytes were stained with CD19 APC and IgG (clone M1310G05) Biotin (top) or rat IgG2a, κ Biotin isotype control (bottom).
  • M1310G05_Biotin_IgG_Fc_Antibody_1_103117
    Human peripheral blood lymphocytes were stained with CD19 APC and IgG (clone M1310G05) Biotin (top) or rat IgG2a, κ Biotin isotype control (bottom).
  • M1310G05_Biotin_IgG_Fc_Antibody_2_103117
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410718 100 µg $223
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IgG Fc is a homodimer that is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc fragment mediates opsonization, antibody dependent cellular cytotoxicity (ADCC), and complement activation through binding to Fc receptors such as CD16, CD32, CD64, and the complement factor C1.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Human Siglec-E-IgG Fc fusion protein.
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone M1310G05 recognizes IgG in the membrane of memory B cells, has a stronger affinity for IgG1 and IgG3 than for IgG2 and IgG4, and does not cross react with IgD, IgE, or IgM.

Product Citations
  1. Ge J, et al. 2021. Nat Commun. 0.673611111. PubMed
  2. Sachar C, et al. 2021. Front Immunol. 12:704693. PubMed
  3. Wang R, et al. 2022. Front Immunol. 13:854952. PubMed
  4. Wang R, et al. 2021. Immunity. 54:1611. PubMed
  5. Yan R, et al. 2021. Cell Res. . PubMed
AB_2721499 (BioLegend Cat. No. 410718)

Antigen Details

Homodimer formed by the constant region of the IgG heavy chain.
CD16, CD32, and CD64.
Cell Type
B cells
Biology Area
Antigen References

1. Paul, WE. (2003). Fundamental Immunology. Philadelphia, PA: Lippincott, Williams, & Wilkins.

Gene ID
3500 View all products for this Gene ID
View information about IgG Fc on

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 0    Revision Date: 10/31/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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