APC/Cyanine7 anti-human CD146 Antibody

Pricing & Availability
P1H12 (See other available formats)
Regulatory Status
HCDM listed
Other Names
Muc-18, MCAM, Mel-CAM, S-endo
Mouse IgG1, κ
Ave. Rating
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Product Citations
Human cervical cancer cell line, HeLa, was stained with anti-human CD146 APC/Cyanine7 (filled histogram) (clone P1H12) or mouse IgG1, κ APC/Cyanine7 isotype control (open histogram).
  • P1H12_APCCy7_CD146_Antibody_062921.png
    Human cervical cancer cell line, HeLa, was stained with anti-human CD146 APC/Cyanine7 (filled histogram) (clone P1H12) or mouse IgG1, κ APC/Cyanine7 isotype control (open histogram).
Compare all formats See APC/Cyanine7 spectral data
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361041 25 tests $165
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361042 100 tests $387
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CD146 is a 118 kD integral transmembrane glycoprotein that is also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). It belongs to the immunoglobulin superfamily. CD146 is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Reported Reactivity
Mouse, Dog, Rabbit
Antibody Type
Host Species
Cultured human umbilical cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats of this clone) include: Western blotting3 and IHC1,5

Clone P1H12 cross-reacts to Dog2, 5.

Application References

(PubMed link indicates BioLegend citation)
  1. Solovey A, et al. 1997. N. Engl. J. Med. 337:1584. (FC, IHC)
  2. Lamerato-Kozicki AR, et al. 2006. Exp. Hematol. 34:870. (FC)
  3. Balint K, et al. 2005. J. Clin. Invest. 115:3166. (WB)
  4. Neskey DM, et al. 2008. J. Exp. Clin. Cancer Res. 27:61. (ELISA)
  5. Kamstock D, et al. 2006. Cancer Gene Therap. 13:306. (IHC)
AB_2894492 (BioLegend Cat. No. 361041)
AB_2894492 (BioLegend Cat. No. 361042)

Antigen Details

118 kD integral glycoprotein, Ig superfamily

Melanoma cells, epithelial cells, endothelial cells, activated T cells, multipotent mesenchymal stromal cells

Adhesion, monocytes transendothelial migration
Cell Type
Endothelial cells, Epithelial cells, Mesenchymal cells, Mesenchymal Stem Cells, T cells
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Pickl WF, et al. 1997. J. Immunol. 158:2107.
2. Weninger W, et al. 2000. J. Invest. Dermatol. 115:219.
3. Sorrentino A, et al. 2008. Exp. Hematol. 36:1035.
4. Bardin N, et al. 2009. Arterioscler. Thromb. Vasc. Biol. 29:746.

Gene ID
4162 View all products for this Gene ID
View information about CD146 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 12/16/2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • PE anti-human CD146

  • Purified anti-human CD146

  • Brilliant Violet 421™ anti-human CD146

  • PE/Cyanine7 anti-human CD146

  • PerCP/Cyanine5.5 anti-human CD146

  • FITC anti-human CD146

  • Alexa Fluor® 647 anti-human CD146

  • APC anti-human CD146

  • TotalSeq™-A0134 anti-human CD146

  • Brilliant Violet 605™ anti-human CD146

  • Brilliant Violet 510™ anti-human CD146

  • Alexa Fluor® 488 anti-human CD146

  • APC/Fire™ 750 anti-human CD146

  • PE/Dazzle™ 594 anti-human CD146

  • Brilliant Violet 785™ anti-human CD146

  • Brilliant Violet 711™ anti-human CD146

  • PE/Cyanine5 anti-human CD146

  • Biotin anti-human CD146

  • TotalSeq™-C0134 anti-human CD146

  • TotalSeq™-B0134 anti-human CD146 Antibody

  • APC/Cyanine7 anti-human CD146


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