APC anti-mouse MERTK (Mer) Antibody

Pricing & Availability
Clone
2B10C42 (See other available formats)
Other Names
Mer, Eyk, Nyk, nmf12
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
2B10C42_APC_MERTK_Antibody_1_011017
C57BL/6 mouse splenocytes were stained with CX3CR1 PE and MERTK (clone 2B10C42) APC (top) or rat IgG2a, κ APC isotype control (bottom).
  • 2B10C42_APC_MERTK_Antibody_1_011017
    C57BL/6 mouse splenocytes were stained with CX3CR1 PE and MERTK (clone 2B10C42) APC (top) or rat IgG2a, κ APC isotype control (bottom).
  • 2B10C42_APC_MERTK_Antibody_2_011017
See APC spectral data
Cat # Size Price Quantity Avail. Save
151507 25 µg $105
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151508 100 µg $285
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Description

MerTK (Mer) is a member of the TAM (TYRO3/AXL/MerTK) family. It is a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. MerTK is mainly expressed by macrophages, monocytes, and dendritic cells. Its ligands are LGALS3, TUB, TULP1, and GAS6. MerTK is involved in the regulation of TLR signaling, efferocytosis, phagocytosis, cell survival, macrophage migration, and the inhibition of inflammation.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse MERTK extracellular domain
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2650738 (BioLegend Cat. No. 151507)
AB_2650739 (BioLegend Cat. No. 151508)

Antigen Details

Structure
Member of the TAM (TYRO3/AXL/MerTK) family. Encodes a transmembrane protein, two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain.
Distribution
Macrophages, monocytes, and dendritic cells.
Function
Regulates TLR signaling, efferocytosis, phagocytosis, cell survival, and macrophage migration. Inhibits production of inflammatory cytokines.
Interaction
Grb2, LimD4, and Vav1.
Ligand/Receptor
LGALS3, TUB, TULP1, and GAS6.
Cell Type
Macrophages, Monocytes, Dendritic cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Costimulatory Molecules
Molecular Family
Toll Like Receptors
Antigen References

1. Zagórska A, et al. 2014. Nat. Immunol. 15:920.
2. Toda S, et al. 2014. Blood 123:3963.
3. Chung WS, et al. 2013. Nature 504:394.
4. Carrera Silva EA, et al. 2013. Immunity 39:160.
5. Yi Z, et al. 2009. Blood 114:3191.

Gene ID
17289 View all products for this Gene ID
UniProt
View information about MERTK on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 01/10/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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