APC anti-mouse IL-33Rα (ST2) Antibody

Pricing & Availability
DIH4 (See other available formats)
Regulatory Status
Other Names
ST2, ST2L, IL-1R1
Rat IgG1, κ
Ave. Rating
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Product Citations
Mouse Th2 clone D10.G4.1 was stained with APC anti-mouse IL-33Rα (clone DIH4, filled histogram) or APC rat IgG1, κ isotype control (open histogram).
  • DIH4_APC_IL-33Ra_Antibody_030118
    Mouse Th2 clone D10.G4.1 was stained with APC anti-mouse IL-33Rα (clone DIH4, filled histogram) or APC rat IgG1, κ isotype control (open histogram).
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146605 25 µg $137
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146606 100 µg $355
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IL-33Ra, also known as ST2 or IL-1RL1 is a member of the Toll/IL-1 receptor family. It binds IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist – soluble form known as ST2 and membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells whereas the soluble form is expressed by serum-stimulated fibroblasts.

Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis has been reported to be important across a range of diseases including asthma, allergies and cardiac disease.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
IL-33Rα-hFcγ 1 fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Hashiguchi M, et al. 2014. Eur. J. Immunology. (FC, Block) PubMed
Product Citations
  1. Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
  2. Satoh–Takayama N, et al. 2020. Immunity. 52(4):635-649. PubMed
AB_2728174 (BioLegend Cat. No. 146605)
AB_2728175 (BioLegend Cat. No. 146606)

Antigen Details

Approximately 63kD, IL-1 receptor family member, single pass type I membrane protein

Mast cells, Th2 cells and fibroblasts

Interacts with IL-33 and recruits MyD88, Irak1, Irak4 and Traf6 followed by phosphorylation of the MAP/ERK pathway
Interacts with MyD88, Irak1, Irak4 and Traf6
Cell Type
Fibroblasts, Mast cells, Th2
Biology Area
Immunology, Innate Immunity
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
  1. Yanagisawa K, et al. 1993. FEBS Lett. 318:83.
  2. Schmitt E, et al. 1990. Cytokine. 6:407.
  3. Yanagisawa K, et al. 1992. FEBS Lett. 302:51.
  4. Takagi T, et al. 1993. Biochim. Biophys. Acta. 1178:194.
Gene ID
17082 View all products for this Gene ID
View information about IL-33Ralpha on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03/02/2018

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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