- 8F2.F9 (See other available formats)
- Regulatory Status
- Other Names
- Major Histocompatibility Complex Class I-related, HLALS
- Mouse IgG1, κ
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- Product Citations
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MHC-related protein 1, also known as MR1, is a nonclassical MHC class I molecule highly conserved in mammals, particularly in its α1/α2 domains. MR1 is required for the development and expansion of the mucosal-associated invariant T (MAIT) cells. The transcripts for MR1 are ubiquitously expressed, but its expression on the cell surface seems to be ligand-dependent. MR1 is involved in the presentation of vitamin-derived compounds from bacterial biosynthetic pathways.Product Details
- Human, Mouse, Rat, Cow
- Antibody Type
- Host Species
- Chimeric mMR1/L molecule (mMR1 [alpha1-alpha2 domain]/Ld [alpha3 cytoplasmic tail]) soluble, recombinant protein secreted by insect cells was used to immunize MR1 KO mice
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
This antibody is noted to cross-react to over-expressed mouse, rat, bovine (cow) and human MR11. This clone does not cross-block clone 26.5 based on in-house testing.
(PubMed link indicates BioLegend citation)
- Chua WJ, et al. 2011. J Immunol. 186:4744-50
AB_2814363 (BioLegend Cat. No. 396103)
AB_2814364 (BioLegend Cat. No. 396104)
- Member of the MHC class I family, 1 Ig-like C1-type domain, forms heterodimer with B-2 Microglobulin.
MR1 transcripts are ubiquitously expressed, but its expression in the cell surface seems to be ligand-dependent.
- Antigen presentation, required for development and expansion of the mucosal-associated invariant T (MAIT) cells.
- α-mannosyl ceramide derivatives, 6-formyl pterin, derivatives from bacterial riboflavin biosynthetic pathway).
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- MHC Antigens
- Antigen References
- Gold MC and Lewinsohn DM. 2013. Nat Rev Microbiol. 11:14.
- Young MH and Gapin L. 2013. Cell Res. 23:460.
- Gold MC, et al. 2013. Mucosal Immunol. 6:35.
- Meierovics A, et al. 2013. Proc Natl Acad Sci USA. 110:E3119.
- Gene ID
- 3140 View all products for this Gene ID 15064 View all products for this Gene ID 25119 View all products for this Gene ID
- View information about MR1 on UniProt.org
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