APC anti-human CD81 (TAPA-1) Antibody

Pricing & Availability
5A6 (See other available formats)
Regulatory Status
Other Names
S5.7, CVID6, TSPAN28
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes were stained with anti-human CD81 (clone 5A6) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
  • 5A6_APC_CD81_Antibody_FC_081214.jpg
    Human peripheral blood lymphocytes were stained with anti-human CD81 (clone 5A6) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
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349509 25 tests $107
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349510 100 tests $308
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CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1 (target of an antiproliferative antibody). CD81 is expressed on T and B cells, NK cells, monocytes, dendritic cells, thymocytes, endothelial cells, and fibroblasts. It also has low levels of expression on granulocytes. CD81 induces B cell adhesion via VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8, and CD82 in T cells.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
Human OCI-LY8 cell line
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: Western Blotting3 and immunoprecipitation2,3.

Application References

(PubMed link indicates BioLegend citation)
  1. Menno C, et al. 2010. J. Clin. Invest. 4:1265.
  2. Oren R, et al. 1990. Mol. Cell. Biol. 8:4007. (IP)
  3. Clark K, et al. 2004. J. Biol. Chem. 279(19):19401. (IP, WB)
  4. Mochida K, et al. 2008. J. Virol. 13:6711.
  5. Rappa G, et al. 2014. Mol Cancer Res. 12:1840. PubMed
Product Citations
  1. Ragni E, et al. 2021. Cells. 10: . PubMed
  2. Boruchowicz H, et al. 2020. J Virol. :94. PubMed
  3. Ragni E, et al. 2022. Biomolecules. 12:. PubMed
  4. Ragni E, et al. 2022. Pharmaceutics. 14:. PubMed
  5. Ragni E, et al. 2020. Stem Cell Res Ther. 165:11. PubMed
  6. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  7. Angeloni N, et al. 2016. Sci Rep. 6:22915. PubMed
  8. Zimmerman B et al. 2016. Cell. 167(4):1041-1051 . PubMed
  9. Najm FJ, et al. 2018. Nat Biotechnol. 36:179. PubMed
  10. Samelson AJ, et al. 2022. Nat Cell Biol. 24:24. PubMed
  11. Alerasool N, et al. 2020. Nat Methods. 17:1093. PubMed
  12. Papait A, et al. 2022. Front Immunol. 13:960909. PubMed
AB_2564020 (BioLegend Cat. No. 349509)
AB_2564021 (BioLegend Cat. No. 349510)

Antigen Details

26 kD, type III transmembrane protein, member of the TM4SF tetraspanin family. Complexed with CD82, CD19, CD21, or CD4, CD8.

T cells, NK, monocytes, B cells, endothelial and epithelial cells, low on granulocytes.

Regulates cell activation and growth and cell aggregation.
Cell Type
B cells, Endothelial cells, Epithelial cells, Monocytes, Neural Stem Cells, NK cells, T cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Signal Transduction, Stem Cells, Transcription Factors
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Menno C, et al. 2010. J. Clin. Invest. 120:1256.
  2. Fearon D, et al. 1995. Annu. Rev. Immunol. 13:127.
  3. Wright M, et al. 1994. Immunol. Today 15:588.
Gene ID
975 View all products for this Gene ID
View information about CD81 on UniProt.org

Related FAQs

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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