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APC anti-human CD5 Antibody

Pricing & Availability
Clone
UCHT2 (See other available formats)
Regulatory Status
RUO
Workshop
III 518
Other Names
Leu-1, Ly-1, T1, Tp67
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
UCHT2_APC_060607
Human peripheral blood lymphocytes were stained with CD5 (UCHT2) APC (filled histogram) or mouse IgG1, κ APC (open histogram).
  • UCHT2_APC_060607
    Human peripheral blood lymphocytes were stained with CD5 (UCHT2) APC (filled histogram) or mouse IgG1, κ APC (open histogram).
Compare all formats See APC spectral data
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300611 25 tests $123
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300612 100 tests $270
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Description

CD5 is a 67 kD single chain type I glycoprotein also known as Leu-1, Ly-1 and T1. It is a member of the scavenger receptor superfamily found on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions upon binding to ligands such as CD72.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee, Capuchin Monkey, Common Marmoset, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: Western blotting2 and immunohistochemical staining of acetone-fixed frozen sections2,5.

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W, et al. 1989. Leucocyte Typing IV Oxford University Press. New York.
  2. Renaudineau Y, et al. 2005. Blood 106:2781. (WB IHC)
  3. Porter JC and Hogg N. 1997. J. Cell Biol. 138:1437.
  4. Saliba AE, et al. 2010. P. Natl. Acad. Sci. USA 107:14524. PubMed
  5. Kap Y, et al. 2009. J. Histochem. Cytochem. 57:1159. (IHC)
Product Citations
  1. Kumar A, et al. 2020. Bio Protoc. 10:e3675. PubMed
  2. Sitlinger A, et al. 2021. Cells. 10:. PubMed
  3. Pulte D, et al. 2011. Clin Lymphoma Myeloma Leuk. 11:367. PubMed
  4. Wierzbinska JA, et al. 2020. Genome Med. 12:29. PubMed
  5. Montel‐Hagen A et al. 2019. Cell stem cell. 24(3):376-389 . PubMed
  6. Celis‐Gutierrez J et al. 2019. Cell Rep. 27(11):3315-3330 . PubMed
RRID
AB_314097 (BioLegend Cat. No. 300611)
AB_314098 (BioLegend Cat. No. 300612)

Antigen Details

Structure
Scavenger receptor superfamily, 67 kD
Distribution

T cells, thymocytes, B cell subset, B cell CLL, peripheral blood dendritic cells

Function
Modulates TCR, BCR signaling, thymocyte maturation, T-B cell interaction
Ligand/Receptor
CD72
Cell Type
B cells, Dendritic cells, Leukemia, T cells, Thymocytes
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Kipps T. 1988. Adv. Immunol. 47:117.
2. Resnick D, et al. 1993. Trends Biochem. Sci. 19:5.
3. Wood GS, et al. 1992. Am. J. Pathol. 14:789.

Gene ID
921 View all products for this Gene ID
UniProt
View information about CD5 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 12/15/2021

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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