- Clone
- 50C1 (See other available formats)
- Workshop
- HCDM listed
- Other Names
- CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes were stained with anti-human CD371 (CLEC12A, clone 50C1) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
| Cat # | Size | Price | Quantity Avail. | Save | ||
|---|---|---|---|---|---|---|
| 353605 | 25 tests | $115 | ||||
| 353606 | 100 tests | $285 | ||||
CD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family. It is expressed on monocytes, granulocytes, NK cells, and basophils. Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- 293T cells expressing CLEC12A-Flag
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Red Laser (633 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Lahoud MH, et al. 2009. J. Immunol. 182:7587. (FC)
- Lahoud MH, et al. 2011. J. Immunol. 187:842. (FC)
- Neumann K, et al. 2014. Immunity. 40:389. PubMed
- RRID
-
AB_2563396 (BioLegend Cat. No. 353605)
AB_2563397 (BioLegend Cat. No. 353606)
Antigen Details
- Structure
- Type II C-type lectin family member, 265 aa, 30.7 kD
- Distribution
-
Monocytes, granulocytes, NK cells, and basophils
- Function
- Negative regulator of granulocyte and monocyte function
- Interaction
- PTPN6 and PTPN11
- Cell Type
- Basophils, Dendritic cells, Granulocytes, Monocytes, NK cells
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
-
1. Lahoud MH, et al. 2009. J. Immunol. 182:7587.
2. Chen CH, et al. 2006. Blood 107:1459.
3. Marshall AS, et al. 2004. J. Biol. Chem. 279:14792. - Gene ID
- 160364 View all products for this Gene ID
- UniProt
- View information about CD371 on UniProt.org
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