- 8F9 (See other available formats)
- Regulatory Status
- HCDM listed
- Other Names
- C-type lectin family member 9A, CD370
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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CD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the transmembrane domain by a stalk region, and an intracellular cytoplasmic tail with immunoreceptor tyrosine-based activation motif (ITAM). In humans, CLEC9A is strictly expressed on BDCA3-positive conventional dendritic cells (cDC) and CD16- monocytes. CLEC9A recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Product Citations
AB_2565518 (BioLegend Cat. No. 353805)
AB_2565519 (BioLegend Cat. No. 353806)
- Type II transmembrane glycoprotein; consists of a 35 amino acid (aa) cytoplasmic domain with an ITAM like motif, a 21 aa transmembrane segment, a 185 aa extracellular domain (ECD) that contains a stalk region, and one C-type lectin domain (CTLD).
Dendritic subsets including plasmacytoid dendritic cells.
- Cross-present antigen to CTL, phagocytosis necrotic cells.
- Necrotic cells.
- Ubiquitous preformed acid-labile protein associated ligand(s).
- Cell Type
- Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, MHC Antigens
- Antigen References
1. Poulin LF, et al. 2010. J. Exp. Med. 207:1261.
2. Sancho D, et al. 2009. Nature 458:899.
3. Huysamen C, et al. 2008. J. Biol. Chem. 283:16693.
- Gene ID
- 283420 View all products for this Gene ID
- View information about CD370 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD370 Reagents Request Custom Conjugation
|Purified anti-human CD370 (CLEC9A/DNGR1)||8F9||FC|
|PE anti-human CD370 (CLEC9A/DNGR1)||8F9||FC|
|APC anti-human CD370 (CLEC9A/DNGR1)||8F9||FC|
|TotalSeq™-A0207 anti-human CD370 (CLEC9A/DNGR1)||8F9||PG|
|TotalSeq™-C0207 anti-human CD370 (CLEC9A/DNGR1)||8F9||PG|
|TotalSeq™-B0207 anti-human CD370 (CLEC9A/DNGR1)||8F9||PG|
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