APC anti-human CD304 (Neuropilin-1) Antibody

Pricing & Availability
Clone
12C2 (See other available formats)
Other Names
BDCA-4, VEGF165R, NRP1
Isotype
Mouse IgG2a, κ
Ave. Rating
1 reviews
Product Citations
publications
12C2_APC_1_060512
Human peripheral blood mononuclear cells were stained with CD303 PE and CD304 (clone 12C2) APC (top) or mouse IgG2a, κ APC isotype control (bottom). Data shown was gated on the lymphocyte and monocyte populations.
  • 12C2_APC_1_060512
    Human peripheral blood mononuclear cells were stained with CD303 PE and CD304 (clone 12C2) APC (top) or mouse IgG2a, κ APC isotype control (bottom). Data shown was gated on the lymphocyte and monocyte populations.
  • 12C2_APC_2_060512
See APC spectral data
Cat # Size Price Quantity Avail. Save
354505 25 tests $130.00
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354506 100 tests $305.00
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Description

CD304, also known as neuropilin-1, BDCA-4 and VEGF165R, is a 140 kD type I transmembrane protein. Its extracellular region contains 2 CUB, 2 FV/FVIII, and one MAM domain; a soluble isoform is produced by alternative mRNA splicing. CD304 is involved in angiogenesis, neural development, and tumor metastasis. It's expressed by plasmacytoid dendritic cells, thymocytes, neurons, endothelium, and a subset of TFH cells. CD304 is also expressed in several carcinomas, and a high expression of this molecule in prostate cancer correlates with a poor prognosis.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
CD304-Fc Fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
RRID
AB_11219393 (BioLegend Cat. No. 354505)
AB_11219600 (BioLegend Cat. No. 354506)

Antigen Details

Structure
Type I transmembrane protein, 140 kD, 2 complement binding domains (CUB), 2 coagulation factor V/VIII homology domains (FV/FVIII), one meprin, A5, receptor tyrosine phosphatase domain (MAM)
Distribution
Plasmacytoid dendritic cells, thymocytes, subset of follicular helper T cells (TFH), endothelial cells, neurons, some carcinomas
Function
Angiogenesis, neuronal development, tumor metastasis
Ligand Receptor
VEGF165, semaphorin-3A
Antigen References

1. Mizui M and Kikutani H. 2008. Immunity 28:302.
2. Hamerlik P, et al. 2012. J. Exp. Med. 209:507.
3. Karjalainen K, et al. 2011. Blood 117:920.
4. Lepelletier Y, et al. 2007. P. Natl. Acad. Sci. USA 104:5545.

Gene ID
8829 View all products for this Gene ID
UniProt
View information about CD304 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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