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APC anti-human CD213a1 (IL-13Rα1) Antibody

Pricing & Availability
Clone
SS12B (See other available formats)
Regulatory Status
RUO
Other Names
NR4, CT19
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
SS12B_APC_IL-13Ra1_Antibody_FC_100713
IL-13Rα1 transfected Burkitt's lymphoma cell line (DND-39) was stained with IL-13Rα1 (clone SS12B) APC (filled histogram), or mouse IgG1, κ APC isotype control (open histogram).
  • SS12B_APC_IL-13Ra1_Antibody_FC_100713
    IL-13Rα1 transfected Burkitt's lymphoma cell line (DND-39) was stained with IL-13Rα1 (clone SS12B) APC (filled histogram), or mouse IgG1, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
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360405 25 tests $161
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360406 100 tests $374
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Description

CD213a1, also known as IL-13Rα1, is a subunit of the IL-13R complex. It can heterodimerize with IL-4R and bind IL-13 with high affinity. IL-13Rα1 by itself binds IL-13 with low affinity compared to IL-13Rα2. It is a 48.7 kD, single pass type I membrane protein. It is expressed at low levels on myeloid cells and on activated T and B cells and Th17 cells. It interacts with TYK2 and may lead to activation of JAK1, STAT3, and STAT6 that is induced by IL-13 and IL-4. It has been implicated to have a role in asthma and allergic responses.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant extracellular domain of human IL-13 receptor α1 chain
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2562625 (BioLegend Cat. No. 360405)
AB_2562626 (BioLegend Cat. No. 360406)

Antigen Details

Structure
Single-pass type I membrane protein 48.7 kD; forms a heterodimer with IL-4R
Distribution

Expressed at low levels on myeloid cells; also expressed on activated T and B cells, Th17 cells

Function
Functional receptor for IL-13
Interaction
Interacts with TYK2 and can lead to downstream activation of JAK1, STAT3, and STAT6
Ligand/Receptor
IL-13
Cell Type
B cells, T cells, Th17
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Aman MJ, et al. 1996. J. Biol. Chem. 271:29265.
2. Osawa M, et al. 2000. Immunogenetics. 51:974.
3. Arima K, et al. 2005. J. Biol. Chem. 280:24915.
4. LaPorte SL, et al. 2008. Cell. 132:259.
5. Newcomb DC, et al. 2011. J. Allerg. Clin. Immunol. 127:1006.

Gene ID
3597 View all products for this Gene ID
UniProt
View information about CD213a1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 10/16/2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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