- 9B10 (See other available formats)
- Other Names
- Evi27, IL-17ER, IL17RH1, IL17br, IL-17 receptor B
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family. IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R. It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells. It binds IL-17B and IL-17E (IL-25) but not IL-17A or C. Its interaction with IL-25 has a higher affinity than that with IL-17B. Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1. IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.Product Details
- Antibody Type
- Host Species
- Recombinant mouse IL-17RB - Fc chimera (human IgG1)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 647.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
- Product Citations
AB_2562380 (BioLegend Cat. No. 146303)
AB_2562381 (BioLegend Cat. No. 146304)
- Single pass type I transmembrane protein, 55.9 kD
- iNKT cells, innate lymphoid cells, Th2 cells
- Binds IL-25 with higher affinity than IL-17B, can block IL-25 mediated pathology
- TRAF6 and Act1
- Cell Type
- NKT cells, Th2
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
1. Hwang SY, et al. 2004. Arthritis Res. Ther. 6:R120.
2. Rickel EA, et al. 2008. J. Immunol. 181:4299.
3. Terashima A, et al. 2008. J. Exp. Med. 205:2727.
- Gene ID
- 50905 View all products for this Gene ID
- View information about IL-17RB on UniProt.org
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