- 12A5 (See other available formats)
- Other Names
- Folate Receptor 4, FBP, FR δ
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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Folate receptor 4 (FR4) is a surface receptor for folic acid (Vitamin B9).It was recently reported that FR4 is highly and constitutively expressed on mouse CD4+ CD25+ natural regulatory T cells (Treg).The high expression of this surface marker on Treg can be used in combination with CD4 and CD25 to distinguish Treg from other types of T cells.Since FR4 is a surface marker,this antibody may be used in combination with anti-CD4 and/or CD25 to sort living T reg cells for functional studies.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 647.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for other applications.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Yamaguchi T et al. 1007:Immunity 27(1)145
- Product Citations
AB_1134201 (BioLegend Cat. No. 125009)
- 28 kd protein consisting of 244 amino acids. Heavily glycosylated
Expressed on mouse thymocytes and spleen cells. Highly expressed on natural regulatory (Treg) cells
- Mediate calcium-independent homophlic cell-cell adhesion
- Ligand Receptor
- Folic acid and its derivative
- Cell Type
- Thymocytes, Tregs
- Biology Area
- Immunology, Innate Immunity
- Antigen References
1. Yamaguchi T et al 2007. Immunity 27:145
2. Spiegelstein O et al. 2000 Gene 258:117
- Gene ID
- 64931 View all products for this Gene ID
- View information about FR4 on UniProt.org
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